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Ork1 Open rectifier K[+] channel 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32020, updated on 2-Nov-2024

Summary

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Official Symbol
Ork1provided by FlyBase
Official Full Name
Open rectifier K[+] channel 1provided by FlyBase
Primary source
FLYBASE:FBgn0017561
Locus tag
Dmel_CG1615
See related
AllianceGenome:FB:FBgn0017561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0161006.1; anon-WO0161006.22; anon-WO0161006.23; CG1615; d-ORK1; Dmel\CG1615; dOrk; dORK; DorK; dOrk1; dORK1; dORKC1; KCNK0; K[[2P]]; ork; Ork; ORK; ORK-1; ork1; ORK1
Summary
Enables potassium ion leak channel activity and protein homodimerization activity. Involved in locomotor rhythm; potassium ion transmembrane transport; and regulation of heart rate. Located in membrane. Part of potassium channel complex. Is expressed in several structures, including adult brain; adult head; adult muscle system; embryonic/larval heart; and ovary. Used to study heart conduction disease. Orthologous to several human genes including KCNK10 (potassium two pore domain channel subfamily K member 10). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Ork1 in Genome Data Viewer
Location:
9F7-9F8; 1-33 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10878054..10891250, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10772087..10785283, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45616 Neighboring gene long non-coding RNA:CR45617

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics. Kollewe A, et al. J Gen Physiol, 2009 Jul. PMID 19564427, Free PMC Article
  2. The involvement of potassium channel ORK1 in short-term memory and sleep in Drosophila. Zhang X, et al. Medicine (Baltimore), 2017 Jul. PMID 28682878, Free PMC Article
  3. Local and global methods of assessing thermal nociception in Drosophila larvae. Chattopadhyay A, et al. J Vis Exp, 2012 May 18. PMID 22643884, Free PMC Article
  4. ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae. Goldstein SA, et al. Proc Natl Acad Sci U S A, 1996 Nov 12. PMID 8917578, Free PMC Article
  5. Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila. Sheeba V, et al. PLoS One, 2010 Jul 16. PMID 20661292, Free PMC Article

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggested that ORK1 might play an important role in the regulation of sleep time and short-term memory in Drosophila.
    Title: The involvement of potassium channel ORK1 in short-term memory and sleep in Drosophila.
  2. The level of Ork1 activity sets the cardiac rhythm by controlling the duration of the slow diastolic depolarization phase.
    Title: Control of cardiac rhythm by ORK1, a Drosophila two-pore domain potassium channel.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium ion leak channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
open rectifier K[+] channel 1
Names
CG1615-PA
CG1615-PB
CG1615-PC
CG1615-PD
Ork1-PA
Ork1-PB
Ork1-PC
Ork1-PD
open rectifier K+ channel 1
open rectifier potassium channel

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    10878054..10891250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167259.3 → NP_727466.1  open rectifier K[+] channel 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727466.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RIM4, Q0KHU1, Q32KC8, Q94526, Q95TX7
    UniProtKB/TrEMBL
    X2JD82
    Related
    FBpp0073261
    Conserved Domains (1) summary
    pfam07885
    Location:90 → 144
    Ion_trans_2; Ion channel

  2. NM_001298167.1 → NP_001285096.1  open rectifier K[+] channel 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285096.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RIM4, Q0KHU1, Q32KC8, Q94526, Q95TX7
    UniProtKB/TrEMBL
    X2JD82
    Conserved Domains (1) summary
    pfam07885
    Location:90 → 144
    Ion_trans_2; Ion channel

  3. NM_078557.5 → NP_511112.1  open rectifier K[+] channel 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511112.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RIM4, Q0KHU1, Q32KC8, Q94526, Q95TX7
    UniProtKB/TrEMBL
    X2JD82
    Related
    FBpp0073260
    Conserved Domains (1) summary
    pfam07885
    Location:90 → 144
    Ion_trans_2; Ion channel

  4. NM_001298168.1 → NP_001285097.1  open rectifier K[+] channel 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285097.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JJC8
    Conserved Domains (1) summary
    pfam07885
    Location:90 → 144
    Ion_trans_2; Ion channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94526.2 Q94526
X2JD82 X2JD82
X2JJC8 X2JJC8

Gene LinkOut

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