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Pgls 6-phosphogluconolactonase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32013, updated on 4-Jul-2024

Summary

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Official Symbol
Pglsprovided by FlyBase
Official Full Name
6-phosphogluconolactonaseprovided by FlyBase
Primary source
FLYBASE:FBgn0030239
Locus tag
Dmel_CG17333
See related
AllianceGenome:FB:FBgn0030239
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6PGL; CG17333; Dm6PGL; Dmel\CG17333; PGLS
Summary
Predicted to enable 6-phosphogluconolactonase activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Pgls in Genome Data Viewer
Location:
9F5-9F5; 1-33 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10847438..10848534)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10741471..10742567)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene small bristles Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene fascetto

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A venom protein of ectoparasitoid Pachycrepoideus vindemiae, PvG6PDH, contributes to parasitism by inhibiting host glucose-6-phosphate metabolism. Yang L, et al. Insect Sci, 2022 Apr. PMID 34724344
  2. Feo, the Drosophila homolog of PRC1, is required for central-spindle formation and cytokinesis. Vernì F, et al. Curr Biol, 2004 Sep 7. PMID 15341744
  3. Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. Bolukbasi E, et al. Open Biol, 2012 Jan. PMID 22645656, Free PMC Article
  4. Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory. de Tredern E, et al. Cell Rep, 2021 Aug 24. PMID 34433052, Free PMC Article
  5. Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis. Bonnay F, et al. Cell, 2020 Sep 17. PMID 32916131

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 6-phosphogluconolactonase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 6-phosphogluconolactonase activity IEA
Inferred from Electronic Annotation
more info
  
enables 6-phosphogluconolactonase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
6-phosphogluconolactonase
Names
CG17333-PA
Pgls-PA
NP_572656.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    10847438..10848534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132428.3 → NP_572656.1  6-phosphogluconolactonase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572656.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53XD9, Q9VZ64
    Related
    FBpp0073235
    Conserved Domains (1) summary
    pfam01182
    Location:14 → 228
    Glucosamine_iso; Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZ64.1 Q9VZ64

Gene LinkOut

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