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Nceh1 neutral cholesterol ester hydrolase 1 [ Mus musculus (house mouse) ]

Gene ID: 320024, updated on 2-Nov-2024

Summary

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Official Symbol
Nceh1provided by MGI
Official Full Name
neutral cholesterol ester hydrolase 1provided by MGI
Primary source
MGI:MGI:2443191
See related
Ensembl:ENSMUSG00000027698 AllianceGenome:MGI:2443191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nceh; CPO-BP; Aadacl1; B230106I24Rik
Summary
Enables phosphate ion binding activity and serine hydrolase activity. Involved in ether lipid metabolic process. Acts upstream of or within protein dephosphorylation and xenobiotic metabolic process. Located in membrane. Is expressed in nervous system; retina; and tooth. Orthologous to human NCEH1 (neutral cholesterol ester hydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 41.2), adrenal adult (RPKM 26.8) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Nceh1 in Genome Data Viewer
Location:
3 A3; 3 10.82 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (27237153..27299112)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (27183004..27245266)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ect2 oncogene Neighboring gene predicted gene, 25152 Neighboring gene RIKEN cDNA 1700125G22 gene Neighboring gene STARR-seq mESC enhancer starr_07226 Neighboring gene STARR-seq mESC enhancer starr_07227 Neighboring gene STARR-seq mESC enhancer starr_07228 Neighboring gene STARR-seq mESC enhancer starr_07232 Neighboring gene STARR-positive B cell enhancer ABC_E6045 Neighboring gene predicted gene, 42192 Neighboring gene STARR-seq mESC enhancer starr_07234 Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene tumor necrosis factor (ligand) superfamily, member 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficiency of neutral cholesterol ester hydrolase 1 (NCEH1) impairs endothelial function in diet-induced diabetic mice. Sun HJ, et al. Cardiovasc Diabetol, 2024 Apr 25. PMID 38664801, Free PMC Article
  2. Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence. Igarashi M, et al. J Lipid Res, 2010 Feb. PMID 19592704, Free PMC Article
  3. Estrogen-dependent activation of neutral cholesterol ester hydrolase underlying gender difference of atherogenesis in apoE-/- mice. Chiba T, et al. Atherosclerosis, 2011 Dec. PMID 21944698
  4. Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages. Sakai K, et al. J Lipid Res, 2014 Oct. PMID 24868095, Free PMC Article
  5. A brain detoxifying enzyme for organophosphorus nerve poisons. Nomura DK, et al. Proc Natl Acad Sci U S A, 2005 Apr 26. PMID 15840715, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of neutral cholesterol ester hydrolase 1 (NCEH1) impairs endothelial function in diet-induced diabetic mice.
    Title: Deficiency of neutral cholesterol ester hydrolase 1 (NCEH1) impairs endothelial function in diet-induced diabetic mice.
  2. These results suggest that Nceh1 plays a dominant role over Lipe in the hydrolysis of CE and subsequent cholesterol efflux in MPMs
    Title: Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages.
  3. reducing the cholesteryl ester content of foam cells, Nceh1 may protect against the pro-apoptotic effect of oxysterols and modulate the development of atherosclerosis.
    Title: Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages.
  4. Gender difference of atherogenesis is partly accounted for activation of neutral cholesterol ester hydrolase through estrogen-dependent translocation of A-kinase type II in macrophages.
    Title: Estrogen-dependent activation of neutral cholesterol ester hydrolase underlying gender difference of atherogenesis in apoE-/- mice.
  5. Nceh1 is involved in the adrenal cholesterol metabolism, and the cholesterol ester hydrolytic activity in adrenal glands is associated with the organ enlargement.
    Title: Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.
  6. NCEH is targeted to the ER of macrophages, where it hydrolyzes CE to deliver cholesterol for efflux out of the cells.
    Title: Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence.
  7. Genetic ablation of Nceh1 promotes foam cell formation and the development of atherosclerosis in mice.
    Title: Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
  8. NCEH is responsible for a major part of nCEH activity in macrophages and may be a potential therapeutic target for the prevention of atherosclerosis.
    Title: Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylalkylglycerol acetylhydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphate ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ether lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within xenobiotic metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neutral cholesterol ester hydrolase 1
Names
2-acetyl MAGE hydrolase
acetylalkylglycerol acetylhydrolase
arylacetamide deacetylase-like 1
chlorpyrifos oxon-binding protein
NP_848887.1
XP_011247986.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178772.4 → NP_848887.1  neutral cholesterol ester hydrolase 1

    See identical proteins and their annotated locations for NP_848887.1

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC157919
    Consensus CDS
    CCDS17271.1
    UniProtKB/Swiss-Prot
    Q69ZL0, Q8BLF1, Q8BZK3
    Related
    ENSMUSP00000045864.9, ENSMUST00000046515.15
    Conserved Domains (2) summary
    COG0657
    Location:73 → 385
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam07859
    Location:109 → 382
    Abhydrolase_3; alpha/beta hydrolase fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    27237153..27299112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249684.2 → XP_011247986.1  neutral cholesterol ester hydrolase 1 isoform X1

    Conserved Domains (1) summary
    cl21494
    Location:1 → 248
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLF1.1 GenPept UniProtKB/Swiss-Prot:Q8BLF1

Gene LinkOut

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