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Agmo alkylglycerol monooxygenase [ Mus musculus (house mouse) ]

Gene ID: 319660, updated on 2-Nov-2024

Summary

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Official Symbol
Agmoprovided by MGI
Official Full Name
alkylglycerol monooxygenaseprovided by MGI
Primary source
MGI:MGI:2442495
See related
Ensembl:ENSMUSG00000050103 AllianceGenome:MGI:2442495
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem195; A530016O06Rik
Summary
Enables glyceryl-ether monooxygenase activity. Involved in triglyceride biosynthetic process. Is active in endoplasmic reticulum membrane. Orthologous to human AGMO (alkylglycerol monooxygenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver adult (RPKM 14.5), large intestine adult (RPKM 8.7) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Agmo in Genome Data Viewer
Location:
12 A3; 12 16.84 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (37291638..37632201)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (37241639..37581932)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31928 Neighboring gene predicted gene 29007 Neighboring gene mesenchyme homeobox 2 Neighboring gene predicted gene, 34408 Neighboring gene STARR-seq mESC enhancer starr_31930 Neighboring gene STARR-seq mESC enhancer starr_31931 Neighboring gene STARR-seq mESC enhancer starr_31932 Neighboring gene STARR-seq mESC enhancer starr_31933 Neighboring gene STARR-seq mESC enhancer starr_31934 Neighboring gene diacylglycerol kinase, beta Neighboring gene STARR-seq mESC enhancer starr_31935 Neighboring gene predicted gene, 35755 Neighboring gene predicted gene, 52011

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown. Sailer S, et al. J Lipid Res, 2022 Jun. PMID 35537527, Free PMC Article
  2. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Schmitz K, et al. Neurotherapeutics, 2021 Jul. PMID 33844153, Free PMC Article
  3. Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome. Watschinger K, et al. Proc Natl Acad Sci U S A, 2015 Feb 24. PMID 25675482, Free PMC Article
  4. Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. Tokuoka SM, et al. Biochem Biophys Res Commun, 2013 Jun 28. PMID 23743196
  5. Alterations in ether lipid metabolism and the consequences for the mouse lipidome. Lackner K, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2023 Apr. PMID 36690320

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glyceryl-ether monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyceryl-ether monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glyceryl-ether monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glyceryl-ether monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables glyceryl-ether monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ether lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ether lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in membrane lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alkylglycerol monooxygenase
Names
transmembrane protein 195
NP_848882.2
XP_011242177.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178767.5 → NP_848882.2  alkylglycerol monooxygenase

    See identical proteins and their annotated locations for NP_848882.2

    Status: PROVISIONAL

    Source sequence(s)
    AK040702
    Consensus CDS
    CCDS49052.1
    UniProtKB/Swiss-Prot
    Q3TR15, Q8BS35, Q8C7H5, Q8CAA6
    Related
    ENSMUSP00000051441.8, ENSMUST00000049874.14
    Conserved Domains (2) summary
    COG3000
    Location:43 → 256
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
    pfam04116
    Location:121 → 249
    FA_hydroxylase; Fatty acid hydroxylase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    37291638..37632201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243875.3 → XP_011242177.1  alkylglycerol monooxygenase isoform X1

    Related
    ENSMUSP00000123801.2, ENSMUST00000159998.8
    Conserved Domains (1) summary
    COG3000
    Location:43 → 256
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]

RNA

  1. XR_004937507.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BS35.1 GenPept UniProtKB/Swiss-Prot:Q8BS35

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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