H2ac1 H2A clustered histone 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2ac1provided by MGI
Official Full Name: H2A clustered histone 1provided by MGI
Primary source: MGI:MGI:2448285
See related: Ensembl:ENSMUSG00000060081 AllianceGenome:MGI:2448285
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Th2a; Hist1h2aa
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Orthologs: human all
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Genomic context

Location:: 13 A3.1; 13 10.0 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (24118420..24118896)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (23934437..23934913)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that a loss of TH2A and TH2B function in chromatin dynamics or a decrease in the total histone levels causes defects in both cohesin release and histone replacement during spermatogenesis.
Title: Disruption of Th2a and Th2b genes causes defects in spermatogenesis.
Crystal structure and functional analyses of nucleosome complexes with mouse histone variants TH2a and TH2b, involved in reprogramming.
Title: Structural and functional analyses of nucleosome complexes with mouse histone variants TH2a and TH2b, involved in reprogramming.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490539

NoName (e-PCR)
- UniSTS:490541

NoName (e-PCR)
- UniSTS:493007

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of chromatin	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IDA Inferred from Direct Assay more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in female germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histone cluster 1, H2aa

Names: histone 1, H2aa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175658.3 → NP_783589.1 histone cluster 1, H2aa

See identical proteins and their annotated locations for NP_783589.1

Status: REVIEWED

Source sequence(s)

AL606464

Consensus CDS

CCDS26374.1

UniProtKB/TrEMBL

A0A0N4SV66, Q8CGP4

Related

ENSMUSP00000072227.2, ENSMUST00000072391.2

Conserved Domains (2) summary

PTZ00017
Location:1 → 127

PTZ00017; histone H2A; Provisional

cd00074
Location:6 → 120

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...