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Sp1 Sp1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31913, updated on 18-Sep-2024

Summary

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Official Symbol
Sp1provided by FlyBase
Official Full Name
Sp1provided by FlyBase
Primary source
FLYBASE:FBgn0020378
Locus tag
Dmel_CG1343
See related
AllianceGenome:FB:FBgn0020378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1343; D-Sp1; D-Sp8; D.Sp1; Dmel\CG1343; dSp1; sp1; SP1
Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including egg chamber; imaginal disc; imaginal disc primordium; presumptive embryonic/larval nervous system; and proneural cluster. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 12. Orthologous to several human genes including SP9 (Sp9 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Sp1 in Genome Data Viewer
Location:
9A1-9A1; 1-30 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9729648..9756369)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9623681..9650402)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene buttonhead Neighboring gene long non-coding RNA:CR43498 Neighboring gene uncharacterized protein Neighboring gene Carbonic anhydrase-related protein B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. buttonhead and D-Sp1: a novel Drosophila gene pair. Wimmer EA, et al. Mech Dev, 1996 Sep. PMID 8892232
  2. Sp1 modifies leg-to-wing transdetermination in Drosophila. Ing T, et al. Dev Biol, 2013 Jan 15. PMID 23165292, Free PMC Article
  3. Cloning and Characterization of Drosophila melanogaster Juvenile Hormone Epoxide Hydrolases (JHEH) and Their Promoters. Borovsky D, et al. Biomolecules, 2022 Jul 16. PMID 35883546, Free PMC Article
  4. Tiny RNAs associated with transcription start sites in animals. Taft RJ, et al. Nat Genet, 2009 May. PMID 19377478
  5. Functional Translational Readthrough: A Systems Biology Perspective. Schueren F, et al. PLoS Genet, 2016 Aug. PMID 27490485, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In vivo analysis of the evolutionary conserved BTD-box domain of Sp1 and Btd during Drosophila development.
    Title: In vivo analysis of the evolutionary conserved BTD-box domain of Sp1 and Btd during Drosophila development.
  2. Differential Contributions of DNA-Binding Proteins to Polycomb Response Element Activity at the Drosophila giant Gene.
    Title: Differential Contributions of DNA-Binding Proteins to Polycomb Response Element Activity at the Drosophila giant Gene.
  3. These studies establish a role for Sp1 in leg-to-wing transdetermination.
    Title: Sp1 modifies leg-to-wing transdetermination in Drosophila.
  4. By simultaneously removing the function of two Sp8 orthologs, buttonhead (btd) and Sp1, during Drosophila embryogenesis, we find that adult leg development is completely abolished.
    Title: Non-redundant selector and growth-promoting functions of two sister genes, buttonhead and Sp1, in Drosophila leg development.
  5. Results show that buttonhead and Sp1 induce the formation and are required for the growth of the ventral imaginal discs.
    Title: The role of buttonhead and Sp1 in the development of the ventral imaginal discs of Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Sp1
Names
CG1343-PB
CG1343-PD
CG1343-PE
CG1343-PF
Sp1-PB
Sp1-PD
Sp1-PE
Sp1-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9729648..9756369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132351.3 → NP_572579.3  Sp1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572579.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    R9PY21
    Conserved Domains (3) summary
    sd00017
    Location:395 → 414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:450 → 472
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:436 → 459
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001103457.4 → NP_001096927.2  Sp1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096927.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUN6
    Conserved Domains (3) summary
    sd00017
    Location:390 → 409
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:445 → 467
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:431 → 454
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001272459.1 → NP_001259388.1  Sp1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259388.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PJG1
    Conserved Domains (3) summary
    sd00017
    Location:390 → 409
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:445 → 467
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:431 → 454
    zf-H2C2_2; Zinc-finger double domain

  4. NM_167200.4 → NP_727360.1  Sp1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727360.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4IJ80, Q8IRM5
    Related
    FBpp0071316
    Conserved Domains (3) summary
    sd00017
    Location:195 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:250 → 272
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:236 → 259
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JUN6 A8JUN6
M9PJG1 M9PJG1
Q8IRM5 Q8IRM5
Q9U1K4 Q9U1K4
R9PY21 R9PY21

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