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t tan [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31863, updated on 18-Sep-2024

Summary

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Official Symbol
tprovided by FlyBase
Official Full Name
tanprovided by FlyBase
Primary source
FLYBASE:FBgn0086367
Locus tag
Dmel_CG12120
See related
AllianceGenome:FB:FBgn0086367
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12120; Dmel\CG12120; Tan
Summary
Enables beta-alanyl-dopamine hydrolase activity and beta-alanyl-histamine hydrolase activity. Involved in cellular biogenic amine biosynthetic process; cuticle pigmentation; and visual perception. Located in cytosol. Is expressed in adult head; embryonic/larval central nervous system; photoreceptor cell; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
8D1-8D1; 1-27 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9217655..9223257, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9111688..9117290, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 8a Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Strong epistatic and additive effects of linked candidate SNPs for Drosophila pigmentation have implications for analysis of genome-wide association studies results. Gibert JM, et al. Genome Biol, 2017 Jul 3. PMID 28673357, Free PMC Article
  2. Sensitivity of Allelic Divergence to Genomic Position: Lessons from the Drosophila tan Gene. John AV, et al. G3 (Bethesda), 2016 Sep 8. PMID 27449514, Free PMC Article
  3. On-transient of insect electroretinogram: its cellular origin. Alawi AA, et al. Science, 1971 Jun 4. PMID 5573957
  4. Separation of receptor and lamina potentials in the electroretinogram of normal and mutant Drosophila. Heisenberg M. J Exp Biol, 1971 Aug. PMID 5001616
  5. Abnormal concentrations of dopamine in a Drosophila mutant. Konopka RJ. Nature, 1972 Sep 29. PMID 4627779

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, we test this assumption by comparing the activity of tan alleles from two Drosophila species, D. americana and D. novamexicana, at five different genomic locations in D. melanogaster We found that the relative effects of these alleles varied among insertion sites, with no difference in activity observed between them at two sites
    Title: Sensitivity of Allelic Divergence to Genomic Position: Lessons from the Drosophila tan Gene.
  2. Interestingly, t was previously shown to be involved in inter-individual variation of female abdominal pigmentation in Drosophila melanogaster, and in abdominal pigmentation divergence between Drosophila species. Sensitivity of t expression to environmental conditions might therefore give more substrate for selection, explaining why this gene has frequently been involved in evolution of pigmentation.
    Title: Phenotypic Plasticity through Transcriptional Regulation of the Evolutionary Hotspot Gene tan in Drosophila melanogaster.
  3. D. melanogaster CG12120 corresponds to tan, a novel hydrolase required in pigmentation and vision
    Title: Drosophila tan encodes a novel hydrolase required in pigmentation and vision.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables beta-alanyl-dopamine hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-alanyl-dopamine hydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables beta-alanyl-histamine hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cuticle pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dopamine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in histamine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in histamine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in visual perception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tan
Names
CG12120-PA
CG12120-PB
Tan
beta-alanyl-dopamine hydrolase
on-transient defective
t-PA
t-PB
NP_001285042.1
NP_572543.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9217655..9223257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132315.1 → NP_572543.1  tan, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572543.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W369
    UniProtKB/TrEMBL
    D7RHE8
    Related
    FBpp0071270, FBtr0071335
    Conserved Domains (1) summary
    pfam03417
    Location:127 → 375
    AAT; Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase

  2. NM_001298113.1 → NP_001285042.1  tan, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285042.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W369
    UniProtKB/TrEMBL
    D7RHE8
    Conserved Domains (1) summary
    pfam03417
    Location:127 → 375
    AAT; Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W369.1 Q9W369

Gene LinkOut

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