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Slimp Seryl-tRNA synthetase-like insect mitochondrial protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318604, updated on 18-Sep-2024

Summary

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Official Symbol
Slimpprovided by FlyBase
Official Full Name
Seryl-tRNA synthetase-like insect mitochondrial proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0051133
Locus tag
Dmel_CG31133
See related
AllianceGenome:FB:FBgn0051133
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD24627; CG31133; Dmel\CG31133; SLIMP
Summary
Enables tRNA binding activity. Located in mitochondrion. Is expressed in several structures, including anlage in statu nascendi; anterior endoderm anlage; dorsal pharyngeal muscle cell; ectoderm anlage; and embryonic/larval midgut. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Slimp in Genome Data Viewer
Location:
95E5-95E5; 3-83 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24147436..24148967, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19973158..19974689, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Secretory 10 Neighboring gene Niemann-Pick type C-2f Neighboring gene Kallmann syndrome 1 Neighboring gene p38c MAP kinase Neighboring gene p38a MAP kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein-Protein Interactions of Seryl-tRNA Synthetases with Emphasis on Human Counterparts and Their Connection to Health and Disease. Dulic M, et al. Life (Basel), 2024 Jan 15. PMID 38255739, Free PMC Article
  2. New aminoacyl-tRNA synthetase-like protein in insecta with an essential mitochondrial function. Guitart T, et al. J Biol Chem, 2010 Dec 3. PMID 20870726, Free PMC Article
  3. Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit. Picchioni D, et al. Cell Rep, 2019 Apr 2. PMID 30943413
  4. The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif. Liu X, et al. Cell Rep, 2015 Dec 15. PMID 26673323, Free PMC Article
  5. Mosaic genetic screen for suppressors of the de2f1 mutant phenotype in Drosophila. Ambrus AM, et al. Genetics, 2009 Sep. PMID 19546319, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A duplication of the gene coding for mitochondrial seryl-tRNA synthetase (SerRS2) generated in arthropods a paralog protein (SLIMP) that forms a heterodimeric complex with a SerRS2 monomer.
    Title: Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit.
  2. New aminoacyl-tRNA synthetase-like protein in insecta with an essential mitochondrial function
    Title: New aminoacyl-tRNA synthetase-like protein in insecta with an essential mitochondrial function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to serine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial seryl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in seryl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of serine-tRNA ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Seryl-tRNA synthetase-like insect mitochondrial protein
Names
CG31133-PA
Slimp-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24147436..24148967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170125.3 → NP_732958.1  Seryl-tRNA synthetase-like insect mitochondrial protein [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732958.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95T19
    Related
    FBpp0083968
    Conserved Domains (3) summary
    TIGR00414
    Location:43 → 433
    serS; seryl-tRNA synthetase
    cl00268
    Location:194 → 433
    class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
    cl12057
    Location:51 → 150
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95T19.1 Q95T19

Gene LinkOut

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