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CG12118 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31857, updated on 18-Sep-2024

Summary

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Official Symbol
CG12118provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030101
Locus tag
Dmel_CG12118
See related
AllianceGenome:FB:FBgn0030101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12118
Summary
Predicted to be involved in cobalamin metabolic process. Located in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblD. Orthologous to human MMADHC (metabolism of cobalamin associated D). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CG12118 in Genome Data Viewer
Location:
8D1-8D1; 1-27 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9194750..9196414, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9088783..9090447, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene suppressor of rudimentary Neighboring gene SET and MYND domain containing, arthropod-specific, member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of pyrimidine catabolism in Drosophila melanogaster using epistatic interactions with mutations of pyrimidine biosynthesis and beta-alanine metabolism. Rawls JM Jr. Genetics, 2006 Mar. PMID 16361227, Free PMC Article
  2. Systematic screening of a Drosophila ORF library in vivo uncovers Wnt/Wg pathway components. Schertel C, et al. Dev Cell, 2013 Apr 29. PMID 23583758
  3. A genome-wide resource for the analysis of protein localisation in Drosophila. Sarov M, et al. Elife, 2016 Feb 20. PMID 26896675, Free PMC Article
  4. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235
  5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cobalamin metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cobalamin metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12118-PA
CG12118-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9194750..9196414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176720.2 → NP_788893.1  uncharacterized protein Dmel_CG12118, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788893.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W375
    Related
    FBpp0071275
    Conserved Domains (1) summary
    pfam10229
    Location:22 → 275
    DUF2246; Uncharacterized conserved protein (DUF2246)

  2. NM_132309.3 → NP_572537.1  uncharacterized protein Dmel_CG12118, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572537.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W375
    Related
    FBpp0071274
    Conserved Domains (1) summary
    pfam10229
    Location:22 → 275
    DUF2246; Uncharacterized conserved protein (DUF2246)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W375 Q9W375

Gene LinkOut

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