SLC9A1 solute carrier family 9 member A1 [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: SLC9A1
Gene description: solute carrier family 9 member A1
See related: BGD:BT27006; Ensembl:ENSBTAG00000008766
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	2	NC_037329.1 (126090704..126141637)

Chromosome 2 - NC_037329.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study evaluated the role for NHE-1 in diabetic cataract formation and retinal oxidative stress and apoptosis.
Title: Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis.
Results support the hypothesis that a blood-brain barrier Na/H exchanger, possibly NHE1 and/or NHE2, is stimulated during ischemia to participate in cerebral edema formation.
Title: Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of pH	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: sodium/hydrogen exchanger 1

Names: NHE-1; Na(+)/H(+) exchanger 1; sodium proton exchanger; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174833.2 → NP_777258.1 sodium/hydrogen exchanger 1

See identical proteins and their annotated locations for NP_777258.1

Status: PROVISIONAL

Source sequence(s)

U49432

UniProtKB/Swiss-Prot

F1MHK2, Q28036

Related

ENSBTAP00000048292.2, ENSBTAT00000055788.3

Conserved Domains (3) summary

TIGR00840
Location:95 → 660

b_cpa1; sodium/hydrogen exchanger 3

pfam00999
Location:105 → 503

Na_H_Exchanger; Sodium/hydrogen exchanger family

pfam16644
Location:602 → 700

NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin