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ND-75 NADH dehydrogenase (ubiquinone) 75 kDa subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31762, updated on 2-Nov-2024

Summary

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Official Symbol
ND-75provided by FlyBase
Official Full Name
NADH dehydrogenase (ubiquinone) 75 kDa subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0017566
Locus tag
Dmel_CG2286
See related
AllianceGenome:FB:FBgn0017566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2286; Dmel\CG2286; dNDUFS1; ND75; NDUFS1; NDUS1; NUAM
Summary
Predicted to enable iron-sulfur cluster binding activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in cellular respiration; mitochondrial respiratory chain complex I assembly; and reactive oxygen species metabolic process. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; ganglia; and mesoderm. Used to study mitochondrial metabolism disease and nuclear type mitochondrial complex I deficiency 5. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See ND-75 in Genome Data Viewer
Location:
7E1-7E1; 1-23 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8248651..8251687, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8142684..8145720, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene sniffer Neighboring gene Thioredoxin reductase 1 Neighboring gene uncharacterized protein Neighboring gene Companion of reaper Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Drosophila model of mitochondrial disease phenotypic heterogeneity. Granat L, et al. Biol Open, 2024 Feb 15. PMID 38304969, Free PMC Article
  2. Mitochondrial complex I derived ROS regulate stress adaptation in Drosophila melanogaster. Scialò F, et al. Redox Biol, 2020 May. PMID 32146156, Free PMC Article
  3. Glia are critical for the neuropathology of complex I deficiency in Drosophila. Hegde VR, et al. Hum Mol Genet, 2014 Sep 1. PMID 24760769, Free PMC Article
  4. Divergence of mitochondrial dna is not corroborated by nuclear dna, morphology, or behavior in Drosophila simulans. Ballard JW, et al. Evolution, 2002 Mar. PMID 11989683
  5. MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network. Elkholi R, et al. Mol Cell, 2019 May 2. PMID 30879903, Free PMC Article

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to NADH dehydrogenase (ubiquinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to NADH dehydrogenase (ubiquinone) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP synthesis coupled electron transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular respiration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IC
Inferred by Curator
more info
 PubMed 
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NADH dehydrogenase (ubiquinone) 75 kDa subunit
Names
CG2286-PA
CG2286-PB
FBpp0071128
NADH ubiquinone oxidoreductase 75 kDa
NADH-ubiquinone oxidoreductase 75 kDa subunit
NADH:ubiquinone oxidoreductase 75 kDa subunit
NADH:ubiquinone reductase 75 kDa subunit
NADH:ubiquinone reductase 75-kD subunit precursor
NADH:ubiquinone reductase 75kD subunit precursor
ND-75-PA
ND-75-PB
NP_511083.1
NP_727255.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    8248651..8251687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078528.3 → NP_511083.1  NADH dehydrogenase (ubiquinone) 75 kDa subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511083.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94511, Q9W3H1
    UniProtKB/TrEMBL
    A4V449, Q6NP42
    Related
    FBpp0071128
    Conserved Domains (5) summary
    smart00929
    Location:123 → 163
    NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
    PRK09130
    Location:42 → 722
    PRK09130; NADH dehydrogenase subunit G; Validated
    cd02773
    Location:263 → 636
    MopB_Res-Cmplx1_Nad11; MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase ...
    pfam09326
    Location:671 → 712
    NADH_dhqG_C; NADH-ubiquinone oxidoreductase subunit G, C-terminal
    pfam13510
    Location:40 → 116
    Fer2_4; 2Fe-2S iron-sulfur cluster binding domain

  2. NM_167152.2 → NP_727255.1  NADH dehydrogenase (ubiquinone) 75 kDa subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727255.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94511, Q9W3H1
    UniProtKB/TrEMBL
    A4V449, Q6NP42
    Related
    FBpp0071129
    Conserved Domains (5) summary
    smart00929
    Location:123 → 163
    NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
    PRK09130
    Location:42 → 722
    PRK09130; NADH dehydrogenase subunit G; Validated
    cd02773
    Location:263 → 636
    MopB_Res-Cmplx1_Nad11; MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase ...
    pfam09326
    Location:671 → 712
    NADH_dhqG_C; NADH-ubiquinone oxidoreductase subunit G, C-terminal
    pfam13510
    Location:40 → 116
    Fer2_4; 2Fe-2S iron-sulfur cluster binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V449 A4V449
Q8MM97 Q8MM97
Q94511.3 Q94511

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