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Bcor BCL6 co-repressor [ Rattus norvegicus (Norway rat) ]

Gene ID: 317346, updated on 2-Nov-2024

Summary

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Official Symbol
Bcorprovided by RGD
Official Full Name
BCL6 co-repressorprovided by RGD
Primary source
RGD:1562735
See related
EnsemblRapid:ENSRNOG00000034240 AllianceGenome:RGD:1562735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562735
Summary
Predicted to enable several functions, including heat shock protein binding activity; histone deacetylase binding activity; and transcription corepressor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of biomineral tissue development; negative regulation of transcription by RNA polymerase II; and specification of axis polarity. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in nucleoplasm. Predicted to be part of BCOR complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in dental caries; eye disease (multiple); and gastrointestinal system cancer (multiple). Orthologous to several human genes including BCOR (BCL6 corepressor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 46.4), Lung (RPKM 39.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bcor in Genome Data Viewer
Location:
Xq12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (13282431..13402254)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (10609756..10729613)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (11570155..11692022)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549122 Neighboring gene uncharacterized LOC134484123 Neighboring gene tRNA methyltransferase activator subunit 11-2, pseudogene 3 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L37A like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of molecular features correlating with tumor immunity in gastric cancer by multi-omics data analysis. He Y, et al. Ann Transl Med, 2020 Sep. PMID 33145269, Free PMC Article
  2. Inhibition of the transcriptional repressor complex Bcl-6/BCoR induces endothelial sprouting but does not promote tumor growth. Buchberger E, et al. Oncotarget, 2017 Jan 3. PMID 27880939, Free PMC Article
  3. Comprehensive mutation profiling of mucinous gastric carcinoma. Rokutan H, et al. J Pathol, 2016 Oct. PMID 27313181
  4. Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy. Agardh E, et al. BMC Med, 2015 Aug 6. PMID 26248552, Free PMC Article
  5. Left-sided embryonic expression of the BCL-6 corepressor, BCOR, is required for vertebrate laterality determination. Hilton EN, et al. Hum Mol Genet, 2007 Jul 15. PMID 17517692

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within blastocyst hatching ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tooth mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in odontogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in roof of mouth development ISO
Inferred from Sequence Orthology
more info
  
involved_in specification of axis polarity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of BCOR complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BCL-6 corepressor
Names
Bcl6 interacting corepressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191586.2 → NP_001178515.1  BCL-6 corepressor isoform 1

    See identical proteins and their annotated locations for NP_001178515.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I5XVI9, D4A2J9
    Related
    ENSRNOP00000098479.2, ENSRNOT00000120870.2
    Conserved Domains (5) summary
    cd14261
    Location:1632 → 1748
    PUFD; PCGF Ub-like fold discriminator of BCOR
    pfam05109
    Location:257 → 672
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1465 → 1496
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1469 → 1560
    Ank_2; Ankyrin repeats (3 copies)
    pfam15808
    Location:1203 → 1415
    BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

  2. NM_001434114.1 → NP_001421043.1  BCL-6 corepressor isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  3. NM_001434115.1 → NP_001421044.1  BCL-6 corepressor isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  4. NM_001434116.1 → NP_001421045.1  BCL-6 corepressor isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  5. NM_001434117.1 → NP_001421046.1  BCL-6 corepressor isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  6. NM_001434118.1 → NP_001421047.1  BCL-6 corepressor isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    13282431..13402254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099760.2 → XP_038955688.1  BCL-6 corepressor isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVI9, D4A2J9
    Conserved Domains (5) summary
    cd14261
    Location:1632 → 1748
    PUFD; PCGF Ub-like fold discriminator of BCOR
    pfam05109
    Location:257 → 672
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1465 → 1496
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1469 → 1560
    Ank_2; Ankyrin repeats (3 copies)
    pfam15808
    Location:1203 → 1415
    BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

  2. XM_063280048.1 → XP_063136118.1  BCL-6 corepressor isoform X3

  3. XM_039099759.2 → XP_038955687.1  BCL-6 corepressor isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVI9, D4A2J9
    Conserved Domains (5) summary
    cd14261
    Location:1632 → 1748
    PUFD; PCGF Ub-like fold discriminator of BCOR
    pfam05109
    Location:257 → 672
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1465 → 1496
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1469 → 1560
    Ank_2; Ankyrin repeats (3 copies)
    pfam15808
    Location:1203 → 1415
    BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

  4. XM_063280047.1 → XP_063136117.1  BCL-6 corepressor isoform X3

  5. XM_039099762.2 → XP_038955690.1  BCL-6 corepressor isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVI9, D4A2J9
    Conserved Domains (5) summary
    cd14261
    Location:1632 → 1748
    PUFD; PCGF Ub-like fold discriminator of BCOR
    pfam05109
    Location:257 → 672
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1465 → 1496
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1469 → 1560
    Ank_2; Ankyrin repeats (3 copies)
    pfam15808
    Location:1203 → 1415
    BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

  6. XM_039099763.2 → XP_038955691.1  BCL-6 corepressor isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVI9, D4A2J9
    Conserved Domains (5) summary
    cd14261
    Location:1632 → 1748
    PUFD; PCGF Ub-like fold discriminator of BCOR
    pfam05109
    Location:257 → 672
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1465 → 1496
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1469 → 1560
    Ank_2; Ankyrin repeats (3 copies)
    pfam15808
    Location:1203 → 1415
    BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

  7. XM_039099766.2 → XP_038955694.1  BCL-6 corepressor isoform X3

    UniProtKB/TrEMBL
    A6K007
    Conserved Domains (5) summary
    cd14261
    Location:1598 → 1714
    PUFD; PCGF Ub-like fold discriminator of BCOR
    pfam05109
    Location:257 → 672
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1431 → 1462
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1435 → 1526
    Ank_2; Ankyrin repeats (3 copies)
    pfam15808
    Location:1169 → 1381
    BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

  8. XM_063280046.1 → XP_063136116.1  BCL-6 corepressor isoform X2

    UniProtKB/TrEMBL
    A0A8I6A262

  9. XM_063280045.1 → XP_063136115.1  BCL-6 corepressor isoform X1

    UniProtKB/TrEMBL
    D4A2J9

  10. XM_039099765.2 → XP_038955693.1  BCL-6 corepressor isoform X2

    UniProtKB/TrEMBL
    A0A8I5XVI9, A0A8I6A262
    Related
    ENSRNOP00000098480.2, ENSRNOT00000120871.2
    Conserved Domains (5) summary
    cd14261
    Location:1614 → 1730
    PUFD; PCGF Ub-like fold discriminator of BCOR
    pfam05109
    Location:257 → 672
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1447 → 1478
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1451 → 1542
    Ank_2; Ankyrin repeats (3 copies)
    pfam15808
    Location:1185 → 1397
    BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

  11. XM_063280049.1 → XP_063136119.1  BCL-6 corepressor isoform X4

  12. XM_039099761.2 → XP_038955689.1  BCL-6 corepressor isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVI9, D4A2J9
    Conserved Domains (5) summary
    cd14261
    Location:1632 → 1748
    PUFD; PCGF Ub-like fold discriminator of BCOR
    pfam05109
    Location:257 → 672
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1465 → 1496
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1469 → 1560
    Ank_2; Ankyrin repeats (3 copies)
    pfam15808
    Location:1203 → 1415
    BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

  13. XM_039099764.2 → XP_038955692.1  BCL-6 corepressor isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVI9, D4A2J9
    Conserved Domains (5) summary
    cd14261
    Location:1632 → 1748
    PUFD; PCGF Ub-like fold discriminator of BCOR
    pfam05109
    Location:257 → 672
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1465 → 1496
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1469 → 1560
    Ank_2; Ankyrin repeats (3 copies)
    pfam15808
    Location:1203 → 1415
    BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
Nucleotide Protein Strain
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