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sws swiss cheese [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31716, updated on 28-Oct-2024

Summary

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Official Symbol
swsprovided by FlyBase
Official Full Name
swiss cheeseprovided by FlyBase
Primary source
FLYBASE:FBgn0003656
Locus tag
Dmel_CG2212
See related
AllianceGenome:FB:FBgn0003656
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2212; Dmel\CG2212; olfE; PNPLA6; Sws; SWS
Summary
Enables lysophospholipase activity and protein kinase A catalytic subunit binding activity. Involved in several processes, including glial cell apoptotic process; photoreceptor cell maintenance; and sensory perception of smell. Located in endoplasmic reticulum membrane and plasma membrane. Is expressed in CNS glial cell; adult brain; adult head; and cell body rind of adult lamina. Used to study blindness; cerebellar ataxia; hereditary spastic paraplegia; and neurodegenerative disease. Human ortholog(s) of this gene implicated in Boucher-Neuhauser syndrome; Laurence-Moon syndrome; Oliver-McFarlane syndrome; and hereditary spastic paraplegia 39. Orthologous to several human genes including PNPLA6 (patatin like phospholipase domain containing 6). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See sws in Genome Data Viewer
Location:
7D1-7D1; 1-22 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7956820..7968236, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7850853..7862269, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ubr3 ubiquitin ligase Neighboring gene antisense RNA:CR45620 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene singed Neighboring gene Tyramine beta hydroxylase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning of an olfactory gene from Drosophila melanogaster. Hasan G. Proc Natl Acad Sci U S A, 1990 Nov. PMID 2123349, Free PMC Article
  2. The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila. Kretzschmar D, et al. J Neurosci, 1997 Oct 1. PMID 9295388, Free PMC Article
  3. Membrane association of and critical residues in the catalytic domain of human neuropathy target esterase. Atkins J, et al. J Biol Chem, 2000 Aug 11. PMID 10816586
  4. Drosophila Lysophospholipase Gene swiss cheese Is Required for Survival and Reproduction. Melentev PA, et al. Insects, 2021 Dec 22. PMID 35055857, Free PMC Article
  5. Characterization of lysophosphatidylcholine-induced changes of intracellular calcium in Drosophila S2 cells. Wang P, et al. Life Sci, 2015 Jun 15. PMID 25736969

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of swiss cheese in Neurons Contributes to Neurodegeneration with Mitochondria Abnormalities, Reactive Oxygen Species Acceleration and Accumulation of Lipid Droplets in Drosophila Brain.
    Title: Loss of swiss cheese in Neurons Contributes to Neurodegeneration with Mitochondria Abnormalities, Reactive Oxygen Species Acceleration and Accumulation of Lipid Droplets in Drosophila Brain.
  2. sws flies showed an activated ER stress response as determined by elevated levels of the chaperone GRP78 and by increased splicing of XBP, an ER transcription factor that activates transcriptional ER stress responses.
    Title: ER responses play a key role in Swiss-Cheese/Neuropathy Target Esterase-associated neurodegeneration.
  3. the loss of SWS in glia impairs neuronal function.
    Title: Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and function.
  4. inducible, neuron-specific expression of full-length human wildtype NTE reduces vacuole formation and substantially rescues mobility.
    Title: Delayed Induction of Human NTE (PNPLA6) Rescues Neurodegeneration and Mobility Defects of Drosophila swiss cheese (sws) Mutants.
  5. OP-modified SWS cannot release PKA-C3 and the resulting loss of PKA-C3 activity plays a crucial role in developing the delayed symptoms of organophosphate-induced delayed neuropathy but not in the acute toxicity
    Title: Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lysophospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophospholipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophospholipase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A catalytic subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ensheathment of neurons IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in membrane organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylcholine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
swiss cheese
Names
CG2212-PA
CG2212-PB
CG2212-PC
olfactory E
olfactory-E
swiss-cheese
swisscheese
sws-PA
sws-PB
sws-PC
NP_511075.3
NP_727224.2
NP_727225.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7956820..7968236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167140.2 → NP_727224.2  swiss cheese, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727224.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJF4
    Conserved Domains (4) summary
    cd07225
    Location:935 → 1240
    Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
    COG0664
    Location:168 → 310
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    COG1752
    Location:940 → 1222
    RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
    cd00038
    Location:620 → 719
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  2. NM_078520.3 → NP_511075.3  swiss cheese, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511075.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8E6M7, Q8IRN7, Q95RE9, Q9U969, Q9W3M0
    Related
    FBpp0071077
    Conserved Domains (4) summary
    cd07225
    Location:935 → 1240
    Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
    COG0664
    Location:168 → 310
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    COG1752
    Location:940 → 1222
    RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
    cd00038
    Location:620 → 719
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  3. NM_167141.3 → NP_727225.1  swiss cheese, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727225.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U969
    Related
    FBpp0071078
    Conserved Domains (1) summary
    cl11396
    Location:1 → 156
    Patatin_and_cPLA2; Patatins and Phospholipases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JJF4 E1JJF4
Q9U969.2 Q9U969

Gene LinkOut

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