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Hira hira [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31680, updated on 2-Nov-2024

Summary

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Official Symbol
Hiraprovided by FlyBase
Official Full Name
hiraprovided by FlyBase
Primary source
FLYBASE:FBgn0022786
Locus tag
Dmel_CG12153
See related
AllianceGenome:FB:FBgn0022786
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12153; Dhh; dhira; dHira; Dmel\CG12153; hira; HIRA; ssm
Summary
Enables chromatin binding activity and histone chaperone activity. Involved in sperm DNA decondensation. Located in germinal vesicle and male germ cell nucleus. Is expressed in nurse cell; oocyte; organism; and ovary. Orthologous to human HIRA (histone cell cycle regulator). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Hira in Genome Data Viewer
Location:
7B7-7B7; 1-20 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7722119..7725917)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7616152..7619950)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Checkpoint suppressor 1-like Neighboring gene long non-coding RNA:CR43287 Neighboring gene uncharacterized protein Neighboring gene NELF-B Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a new gene encoding a member of the HIRA family of proteins from Drosophila melanogaster. Kirov N, et al. Gene, 1998 Jun 8. PMID 9611274
  2. Cloning, chromosome mapping and expression analysis of the HIRA gene from Drosophila melanogaster. Llevadot R, et al. Biochem Biophys Res Commun, 1998 Aug 19. PMID 9712723
  3. Wolbachia-induced cytoplasmic incompatibility is associated with decreased Hira expression in male Drosophila. Zheng Y, et al. PLoS One, 2011 Apr 29. PMID 21559343, Free PMC Article
  4. Mitotic fidelity requires transgenerational action of a testis-restricted HP1. Levine MT, et al. Elife, 2015 Jul 7. PMID 26151671, Free PMC Article
  5. Establishment and maintenance of heritable chromatin structure during early Drosophila embryogenesis. Blythe SA, et al. Elife, 2016 Nov 23. PMID 27879204, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that the HIRA B domain is not essential for paternal chromatin assembly in drosophila.
    Title: ASF1 is required to load histones on the HIRA complex in preparation of paternal chromatin assembly at fertilization.
  2. Intellectual disability-associated BRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3.
    Title: Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3.
  3. we demonstrate that HIRA and YEM proteins interact and are mutually dependent for their targeting to the decondensing male pronucleus.
    Title: Drosophila Yemanuclein and HIRA cooperate for de novo assembly of H3.3-containing nucleosomes in the male pronucleus.
  4. Hira plays an important role in the interaction of Wolbachia and its insect host
    Title: Wolbachia-induced cytoplasmic incompatibility is associated with decreased Hira expression in male Drosophila.
  5. The only essential function of HIRA is the assembly of paternal chromatin during male pronucleus formation.
    Title: The essential role of Drosophila HIRA for de novo assembly of paternal chromatin at fertilization.
  6. the histone chaperone protein HIRA is required for nucleosome assembly during sperm nucleus decondensation
    Title: The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone chaperone activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm DNA decondensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of HIR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in germinal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hira
Names
CG12153-PA
Hira-PA
drosophila hira homolog
drosophila homolog of HIRA
sesame

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7722119..7725917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132173.3 → NP_572401.2  hira [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572401.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17468, O46105, O77144, Q5U0S5, Q8T0C3, Q9W3Q3
    Related
    FBpp0071028
    Conserved Domains (5) summary
    COG2319
    Location:12 → 370
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:14 → 349
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam07569
    Location:629 → 820
    Hira; TUP1-like enhancer of split
    pfam09453
    Location:423 → 442
    HIRA_B; HIRA B motif
    sd00039
    Location:16 → 68
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17468.2 O17468

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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