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Acsf3 Acyl-CoA synthetase family member 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31668, updated on 2-Nov-2024

Summary

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Official Symbol
Acsf3provided by FlyBase
Official Full Name
Acyl-CoA synthetase family member 3provided by FlyBase
Primary source
FLYBASE:FBgn0029945
Locus tag
Dmel_CG18155
See related
AllianceGenome:FB:FBgn0029945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACSF3; CG18155; Dmel\CG18155; FBgn0029945
Summary
Predicted to enable malonyl-CoA synthetase activity and very long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid biosynthetic process and malonate catabolic process. Predicted to be active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined malonic and methylmalonic acidemia. Orthologous to human ACSF3 (acyl-CoA synthetase family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Acsf3 in Genome Data Viewer
Location:
7B1-7B1; 1-20 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7329046..7331255)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7223079..7225288)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44357 Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 5 Neighboring gene uncharacterized protein Neighboring gene Downstream of kinase Neighboring gene sarcoplasmic calcium-binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article
  2. Reduction in mutation frequency by very low-dose gamma irradiation of Drosophila melanogaster germ cells. Ogura K, et al. Radiat Res, 2009 Jan. PMID 19138046
  3. Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila. Li X, et al. Dis Model Mech, 2022 Nov 1. PMID 36305265, Free PMC Article
  4. A Systematic Cell-Based Analysis of Localization of Predicted Drosophila Peroxisomal Proteins. Baron MN, et al. Traffic, 2016 May. PMID 26865094
  5. Rosy Beginnings: Studying Peroxisomes in Drosophila. Pridie C, et al. Front Cell Dev Biol, 2020. PMID 32984330, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables malonyl-CoA synthetase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables very long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables very long-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in malonate catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Acyl-CoA synthetase family member 3
Names
Acsf3-PB
CG18155-PB
NP_996360.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7329046..7331255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206637.4 → NP_996360.2  Acyl-CoA synthetase family member 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996360.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KVU5
    Conserved Domains (2) summary
    COG0318
    Location:53 → 604
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    cl17068
    Location:58 → 607
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KVU5 Q7KVU5

Gene LinkOut

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