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Sphkap SPHK1 interactor, AKAP domain containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 316561, updated on 2-Nov-2024

Summary

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Official Symbol
Sphkapprovided by RGD
Official Full Name
SPHK1 interactor, AKAP domain containingprovided by RGD
Primary source
RGD:1311951
See related
EnsemblRapid:ENSRNOG00000016388 AllianceGenome:RGD:1311951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Skip; RGD1311951
Summary
Predicted to enable protein kinase A binding activity. Predicted to be located in Z disc. Predicted to be active in mitochondrion. Orthologous to human SPHKAP (SPHK1 interactor, AKAP domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 225.5), Brain (RPKM 218.9) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Sphkap in Genome Data Viewer
Location:
9q35
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (91957497..92105834, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (84509383..84657582, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (89050405..89195435, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 20 Neighboring gene dynein assembly factor with WD repeats 1 Neighboring gene small ribosomal subunit protein uS4-like Neighboring gene uncharacterized LOC120094724

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP. Scholten A, et al. J Proteome Res, 2006 Jun. PMID 16739995
  2. Up-regulation of SKIP relates to retinal ganglion cells apoptosis after optic nerve crush in vivo. Wu Y, et al. J Mol Histol, 2014 Dec. PMID 25074585
  3. Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase. Kovanich D, et al. Chembiochem, 2010 May 3. PMID 20394097
  4. Regulation of insulin signaling in skeletal muscle by PIP3 phosphatase, SKIP, and endoplasmic reticulum molecular chaperone glucose-regulated protein 78. Ijuin T, et al. Biochim Biophys Acta, 2015 Dec. PMID 26376412
  5. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Means CK, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22084075, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings underscore the specific and prominent role of SKIP and GRP78 in the regulation of insulin-dependent PI 3-kinase signaling in skeletal muscle
    Title: Regulation of insulin signaling in skeletal muscle by PIP3 phosphatase, SKIP, and endoplasmic reticulum molecular chaperone glucose-regulated protein 78.
  2. Up-regulation of SKIP in the retina is associated with retinal ganglion cells death after optic nerve crush.
    Title: Up-regulation of SKIP relates to retinal ganglion cells apoptosis after optic nerve crush in vivo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
A-kinase anchor protein SPHKAP
Names
SPHK1-interactor and AKAP domain-containing protein
sphingosine kinase type 1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395141.1 → NP_001382070.1  A-kinase anchor protein SPHKAP isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2K3J4
    Related
    ENSRNOP00000091046.2, ENSRNOT00000103600.2
    Conserved Domains (1) summary
    cl14906
    Location:1596 → 1695
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

  2. NM_001395142.1 → NP_001382071.1  A-kinase anchor protein SPHKAP isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A6JWC2, F1LNS0
    Related
    ENSRNOP00000076643.2, ENSRNOT00000113629.2
    Conserved Domains (1) summary
    cl14906
    Location:1625 → 1724
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    91957497..92105834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267237.1 → XP_063123307.1  A-kinase anchor protein SPHKAP isoform X6

    UniProtKB/TrEMBL
    A0A8I6AFF4

  2. XM_006245233.5 → XP_006245295.1  A-kinase anchor protein SPHKAP isoform X4

    UniProtKB/Swiss-Prot
    P0C6C0
    Related
    ENSRNOP00000101111.1, ENSRNOT00000132437.1
    Conserved Domains (1) summary
    cl14906
    Location:1599 → 1699
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

  3. XM_017596483.3 → XP_017451972.1  A-kinase anchor protein SPHKAP isoform X2

    UniProtKB/TrEMBL
    F1LNS0

  4. XM_006245231.5 → XP_006245293.1  A-kinase anchor protein SPHKAP isoform X1

    UniProtKB/TrEMBL
    A0A0G2K3J4
    Related
    ENSRNOP00000100161.1, ENSRNOT00000134158.1
    Conserved Domains (1) summary
    cl14906
    Location:1620 → 1720
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

  5. XM_063267234.1 → XP_063123304.1  A-kinase anchor protein SPHKAP isoform X3

  6. XM_063267235.1 → XP_063123305.1  A-kinase anchor protein SPHKAP isoform X5

    Related
    ENSRNOP00000072661.2, ENSRNOT00000090881.3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001127492.1: Suppressed sequence

    Description
    NM_001127492.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C6C0.1 GenPept UniProtKB/Swiss-Prot:P0C6C0

Gene LinkOut

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