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C3G C3G guanyl-nucleotide exchange factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31618, updated on 18-Sep-2024

Summary

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Official Symbol
C3Gprovided by FlyBase
Official Full Name
C3G guanyl-nucleotide exchange factorprovided by FlyBase
Primary source
FLYBASE:FBgn0259228
Locus tag
Dmel_CG42328
See related
AllianceGenome:FB:FBgn0259228
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
c(3)G; C(3)G; CG14436; CG3126; CG42328; DC3-G; DC3G; Dmel\CG42328
Old locus tag
Dmel_CG14436; Dmel_CG3126
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including muscle attachment; positive regulation of smoothened signaling pathway; and sarcomere organization. Is expressed in several structures, including adult head; embryonic/larval central nervous system; embryonic/larval gut; embryonic/larval somatic muscle cell; and trunk mesoderm. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See C3G in Genome Data Viewer
Location:
6D1-6D2; 1-18 cM
Exon count:
20
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6780790..6803593, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6674823..6697626, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43496 Neighboring gene small ovary Neighboring gene Coenzyme Q7 Neighboring gene shifted Neighboring gene pod1 coronin Neighboring gene inactive

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster. Shirinian M, et al. PLoS One, 2010 Mar 3. PMID 20209136, Free PMC Article
  2. The formation of the central element of the synaptonemal complex may occur by multiple mechanisms: the roles of the N- and C-terminal domains of the Drosophila C(3)G protein in mediating synapsis and recombination. Jeffress JK, et al. Genetics, 2007 Dec. PMID 17947423, Free PMC Article
  3. Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila. Gong Z, et al. J Neurosci, 2004 Oct 13. PMID 15483124, Free PMC Article
  4. X chromosome and autosomal recombination are differentially sensitive to disruptions in SC maintenance. Billmyre KK, et al. Proc Natl Acad Sci U S A, 2019 Oct 22. PMID 31570610, Free PMC Article
  5. Nephrin Signaling Results in Integrin β1 Activation. Dlugos CP, et al. J Am Soc Nephrol, 2019 Jun. PMID 31097607, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A 213-Amino Acid In-Frame Deletion within the Coiled-Coil Region of C(3)G Impairs the Maintenance of the synaptonemal complex in Early to Mid Pachytene.
    Title: X chromosome and autosomal recombination are differentially sensitive to disruptions in SC maintenance.
  2. C3G stimulates guanine nucleotide exchange on Drosophila Rap GTPases in vitro
    Title: The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster.
  3. the N terminus of C(3)G is critical for the formation of antiparallel pairs of C(3)G homodimers that span the central region and thus for assembly of complete TFs, while the C terminus is required to affix these homodimers to the lateral elements.
    Title: The formation of the central element of the synaptonemal complex may occur by multiple mechanisms: the roles of the N- and C-terminal domains of the Drosophila C(3)G protein in mediating synapsis and recombination.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
C3G guanyl-nucleotide exchange factor
Names
C3G ortholog
C3G-PC
C3G-PD
C3G-PE
C3G-PF
C3G-PG
C3G-PH
C3G-PI
C3G-PJ
C3G-PK
C3G-PL
CG42328-PC
CG42328-PD
CG42328-PE
CG42328-PF
CG42328-PG
CG42328-PH
CG42328-PI
CG42328-PJ
CG42328-PK
CG42328-PL

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6780790..6803593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298037.1 → NP_001284966.1  C3G guanyl-nucleotide exchange factor, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284966.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JIR4
    Conserved Domains (2) summary
    smart00229
    Location:956 → 1092
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:1121 → 1344
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  2. NM_176694.3 → NP_788867.1  C3G guanyl-nucleotide exchange factor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788867.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77086
    Related
    FBpp0289069
    Conserved Domains (2) summary
    smart00229
    Location:1119 → 1255
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:1284 → 1507
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  3. NM_001272362.1 → NP_001259291.1  C3G guanyl-nucleotide exchange factor, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259291.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PJ95
    Conserved Domains (2) summary
    smart00229
    Location:1013 → 1149
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:1178 → 1401
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  4. NM_001144695.3 → NP_001138167.1  C3G guanyl-nucleotide exchange factor, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138167.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z129
    Conserved Domains (2) summary
    smart00229
    Location:1016 → 1152
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:1181 → 1404
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  5. NM_001272364.1 → NP_001259293.1  C3G guanyl-nucleotide exchange factor, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259293.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGJ9
    Conserved Domains (2) summary
    smart00229
    Location:1067 → 1203
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:1232 → 1455
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  6. NM_001144696.3 → NP_001138168.1  C3G guanyl-nucleotide exchange factor, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138168.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z130
    Conserved Domains (2) summary
    smart00229
    Location:1067 → 1203
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:1232 → 1455
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  7. NM_001144697.2 → NP_001138169.1  C3G guanyl-nucleotide exchange factor, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138169.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z131
    Conserved Domains (2) summary
    smart00229
    Location:833 → 969
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:998 → 1221
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  8. NM_001144694.2 → NP_001138166.1  C3G guanyl-nucleotide exchange factor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138166.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z132
    Conserved Domains (2) summary
    smart00229
    Location:884 → 1020
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:1049 → 1272
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  9. NM_001272363.1 → NP_001259292.1  C3G guanyl-nucleotide exchange factor, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259292.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z131
    Conserved Domains (2) summary
    smart00229
    Location:833 → 969
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:998 → 1221
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  10. NM_132122.5 → NP_572350.2  C3G guanyl-nucleotide exchange factor, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572350.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77086, Q1ECB6, Q7YU30, Q86B63, Q9W3W3
    Related
    FBpp0289753
    Conserved Domains (2) summary
    smart00229
    Location:1170 → 1306
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:1335 → 1558
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z129 B7Z129
B7Z130 B7Z130
B7Z131 B7Z131
B7Z132 B7Z132
M9PGJ9 M9PGJ9
M9PJ95 M9PJ95
O77086.4 O77086
X2JIR4 X2JIR4

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