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Pomgnt2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) [ Rattus norvegicus (Norway rat) ]

Gene ID: 316091, updated on 28-Oct-2024

Summary

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Official Symbol
Pomgnt2provided by RGD
Official Full Name
protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)provided by RGD
Primary source
RGD:1304827
See related
EnsemblRapid:ENSRNOG00000019492 AllianceGenome:RGD:1304827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ago61; Gtdc2; RGD1304827
Summary
Predicted to enable protein O-acetylglucosaminyltransferase activity. Predicted to be involved in neuron migration and protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A8 and muscular dystrophy-dystroglycanopathy type C8. Orthologous to human POMGNT2 (protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Brain (RPKM 43.3), Muscle (RPKM 29.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pomgnt2 in Genome Data Viewer
Location:
8q32
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (130522607..130538273, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (121645106..121660761, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (130615482..130631144, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene poly(rC) binding protein 2 like 1 Neighboring gene KRAB box domain containing 1 Neighboring gene golgi associated kinase 1A Neighboring gene uncharacterized LOC134480254 Neighboring gene uncharacterized LOC134480253 Neighboring gene uncharacterized LOC120094304 Neighboring gene SNF related kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Milder forms of muscular dystrophy associated with POMGNT2 mutations. Endo Y, et al. Neurol Genet, 2015 Dec. PMID 27066570, Free PMC Article
  2. Ectopic clustering of Cajal-Retzius and subplate cells is an initial pathological feature in Pomgnt2-knockout mice, a model of dystroglycanopathy. Nakagawa N, et al. Sci Rep, 2015 Jun 10. PMID 26060116, Free PMC Article
  3. AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan. Yagi H, et al. Sci Rep, 2013 Nov 21. PMID 24256719, Free PMC Article
  4. SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function. Yoshida-Moriguchi T, et al. Science, 2013 Aug 23. PMID 23929950, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein O-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein O-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked mannosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Names
glycosyltransferase
glycosyltransferase-like domain containing 2
glycosyltransferase-like domain-containing protein 2
NP_001009437.1
XP_008764903.1
XP_008764905.1
XP_038937590.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009437.2 → NP_001009437.1  protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

    See identical proteins and their annotated locations for NP_001009437.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q5NDF0
    UniProtKB/TrEMBL
    A6I471
    Conserved Domains (2) summary
    cd00063
    Location:493 → 580
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl15705
    Location:320 → 395
    DUF563; Protein of unknown function (DUF563)

  2. NM_001433912.1 → NP_001420841.1  protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    130522607..130538273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766681.4 → XP_008764903.1  protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5NDF0
    UniProtKB/TrEMBL
    A6I471
    Related
    ENSRNOP00000098985.1, ENSRNOT00000136071.1
    Conserved Domains (2) summary
    cd00063
    Location:493 → 580
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl15705
    Location:320 → 395
    DUF563; Protein of unknown function (DUF563)

  2. XM_008766683.4 → XP_008764905.1  protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5NDF0
    UniProtKB/TrEMBL
    A6I471
    Related
    ENSRNOP00000108884.1, ENSRNOT00000146834.1
    Conserved Domains (2) summary
    cd00063
    Location:493 → 580
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl15705
    Location:320 → 395
    DUF563; Protein of unknown function (DUF563)

  3. XM_039081662.2 → XP_038937590.1  protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5NDF0
    UniProtKB/TrEMBL
    A6I471
    Conserved Domains (2) summary
    cd00063
    Location:493 → 580
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl15705
    Location:320 → 395
    DUF563; Protein of unknown function (DUF563)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5NDF0.1 GenPept UniProtKB/Swiss-Prot:Q5NDF0

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