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Acad11 acyl-CoA dehydrogenase family, member 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315973, updated on 17-Aug-2024

Summary

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Official Symbol
Acad11provided by RGD
Official Full Name
acyl-CoA dehydrogenase family, member 11provided by RGD
Primary source
RGD:1306270
See related
EnsemblRapid:ENSRNOG00000010940 AllianceGenome:RGD:1306270
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306270
Summary
Predicted to enable medium-chain-acyl-CoA dehydrogenase activity and very-long-chain-acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in peroxisome. Orthologous to human ACAD11 (acyl-CoA dehydrogenase family member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 544.8), Kidney (RPKM 225.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Acad11 in Genome Data Viewer
Location:
8q32
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (113560142..113625346)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (104681346..104746559)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (112594758..112676275)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene nephrocystin 3 Neighboring gene ubiquitin-like modifier activating enzyme 5 Neighboring gene atypical chemokine receptor 4 Neighboring gene uncharacterized LOC120094252 Neighboring gene DnaJ heat shock protein family (Hsp40) member C13 Neighboring gene uncharacterized LOC134480097

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Impact of dietary lipoic acid supplementation on liver mitochondrial bioenergetics and oxidative status on normally fed Wistar rats. Valdecantos MP, et al. Int J Food Sci Nutr, 2019 Nov. PMID 30764676
  2. Identification and characterization of new long chain acyl-CoA dehydrogenases. He M, et al. Mol Genet Metab, 2011 Apr. PMID 21237683, Free PMC Article
  3. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables medium-chain fatty acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables very-long-chain fatty acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
acyl-CoA dehydrogenase family member 11
Names
ACAD-11
acyl-Coenzyme A dehydrogenase family, member 11
NP_001101651.1
XP_038937486.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108181.1 → NP_001101651.1  acyl-CoA dehydrogenase family member 11

    See identical proteins and their annotated locations for NP_001101651.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/Swiss-Prot
    B3DMA2
    UniProtKB/TrEMBL
    A0A8I5ZR07, A0A8I6AMR1
    Related
    ENSRNOP00000036574.4, ENSRNOT00000038383.7
    Conserved Domains (3) summary
    cd01155
    Location:376 → 769
    ACAD_FadE2; Acyl-CoA dehydrogenases similar to fadE2
    PLN02876
    Location:10 → 769
    PLN02876; acyl-CoA dehydrogenase
    cd05154
    Location:42 → 295
    ACAD10_11_N-like; N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    113560142..113625346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081558.2 → XP_038937486.1  acyl-CoA dehydrogenase family member 11 isoform X1

    UniProtKB/TrEMBL
    A0A8L2R5W9
    Related
    ENSRNOP00000072442.2, ENSRNOT00000081281.3
    Conserved Domains (1) summary
    PLN02876
    Location:10 → 539
    PLN02876; acyl-CoA dehydrogenase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B3DMA2.1 GenPept UniProtKB/Swiss-Prot:B3DMA2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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