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Dzip1l DAZ interacting zinc finger protein 1-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 315952, updated on 2-Nov-2024

Summary

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Official Symbol
Dzip1lprovided by RGD
Official Full Name
DAZ interacting zinc finger protein 1-likeprovided by RGD
Primary source
RGD:1311430
See related
EnsemblRapid:ENSRNOG00000014746 AllianceGenome:RGD:1311430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311430
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in cilium assembly and regulation of protein localization. Predicted to act upstream of or within several processes, including ciliary transition zone assembly; neural tube development; and protein localization to cilium. Predicted to be located in axoneme and centriole. Predicted to be active in ciliary basal body and cytoplasm. Human ortholog(s) of this gene implicated in polycystic kidney disease 5. Orthologous to human DZIP1L (DAZ interacting zinc finger protein 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 47.0), Kidney (RPKM 39.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dzip1l in Genome Data Viewer
Location:
8q31
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (109067466..109108390)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (100188414..100229077)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (107875659..107916298)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547387 Neighboring gene alpha-1,4-N-acetylglucosaminyltransferase Neighboring gene claudin 18 Neighboring gene uncharacterized LOC134480090 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. Glazer AM, et al. Dev Biol, 2010 Jan 1. PMID 19852954, Free PMC Article
  2. Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease. Lu H, et al. Nat Genet, 2017 Jul. PMID 28530676, Free PMC Article
  3. Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse. Wang C, et al. Development, 2018 Mar 15. PMID 29487109, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ciliary transition zone assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ciliary transition zone assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in floor plate development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within floor plate development ISO
Inferred from Sequence Orthology
more info
  
involved_in neural tube patterning IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural tube patterning ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cilium IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein localization to cilium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to organelle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axoneme IEA
Inferred from Electronic Annotation
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cilium assembly protein DZIP1L
Names
DAZ interacting protein 1-like
DAZ-interacting protein 1-like protein
zinc finger protein DZIP1L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014095.1 → NP_001014117.1  cilium assembly protein DZIP1L

    See identical proteins and their annotated locations for NP_001014117.1

    Status: VALIDATED

    Source sequence(s)
    BC083786
    UniProtKB/Swiss-Prot
    Q5XIA0
    UniProtKB/TrEMBL
    A0A8L2R8N8, A6I2E2
    Related
    ENSRNOP00000019902.6, ENSRNOT00000019902.7
    Conserved Domains (1) summary
    pfam13815
    Location:24 → 144
    Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    109067466..109108390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243626.5 → XP_006243688.1  cilium assembly protein DZIP1L isoform X1

    See identical proteins and their annotated locations for XP_006243688.1

    UniProtKB/TrEMBL
    A0A8L2R8N8
    Related
    ENSRNOP00000074346.3, ENSRNOT00000090299.3
    Conserved Domains (1) summary
    pfam13815
    Location:24 → 144
    Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal

  2. XM_063265593.1 → XP_063121663.1  cilium assembly protein DZIP1L isoform X2

    UniProtKB/Swiss-Prot
    Q5XIA0
    UniProtKB/TrEMBL
    A6I2E2

  3. XM_006243627.5 → XP_006243689.1  cilium assembly protein DZIP1L isoform X1

    See identical proteins and their annotated locations for XP_006243689.1

    UniProtKB/TrEMBL
    A0A8L2R8N8
    Conserved Domains (1) summary
    pfam13815
    Location:24 → 144
    Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal

  4. XM_063265594.1 → XP_063121664.1  cilium assembly protein DZIP1L isoform X2

    UniProtKB/Swiss-Prot
    Q5XIA0
    UniProtKB/TrEMBL
    A6I2E2

RNA

  1. XR_010053982.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIA0.1 GenPept UniProtKB/Swiss-Prot:Q5XIA0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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