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Cgnl1 cingulin-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315795, updated on 2-Nov-2024

Summary

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Official Symbol
Cgnl1provided by RGD
Official Full Name
cingulin-like 1provided by RGD
Primary source
RGD:1304623
See related
EnsemblRapid:ENSRNOG00000054080 AllianceGenome:RGD:1304623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304623
Summary
Predicted to be involved in several processes, including negative regulation of small GTPase mediated signal transduction; negative regulation of stress fiber assembly; and protein localization to cell-cell junction. Predicted to be located in actin cytoskeleton and apical junction complex. Predicted to be part of protein-containing complex. Predicted to be active in bicellular tight junction. Orthologous to human CGNL1 (cingulin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 795.7), Adrenal (RPKM 182.5) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cgnl1 in Genome Data Viewer
Location:
8q24
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (81154169..81305598, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (72273401..72424842, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (78126670..78278490, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094203 Neighboring gene myocardial zonula adherens protein Neighboring gene dynein light chain LC8-type 1, pseudogene 1 Neighboring gene uncharacterized LOC134480205 Neighboring gene transcription factor 12 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin. Ohnishi H, et al. J Biol Chem, 2004 Oct 29. PMID 15292197
  2. A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells. Pulimeno P, et al. J Biol Chem, 2011 May 13. PMID 21454477, Free PMC Article
  3. Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. Guillemot L, et al. J Cell Sci, 2012 Nov 1. PMID 22946046
  4. Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. Elbediwy A, et al. J Cell Biol, 2012 Aug 20. PMID 22891260, Free PMC Article
  5. ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. Tornavaca O, et al. J Cell Biol, 2015 Mar 16. PMID 25753039, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZO-1 and PLEKHA7 are paracingulin-interacting proteins that are involved in its recruitment to epithelial tight and adherens junctions, respectively
    Title: A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in apical junction complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cingulin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108164.2 → NP_001101634.1  cingulin-like protein 1

    See identical proteins and their annotated locations for NP_001101634.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6AMD9, A6KEQ6, D4A3V5
    Related
    ENSRNOP00000106701.1, ENSRNOT00000131419.1
    Conserved Domains (1) summary
    pfam01576
    Location:617 → 1248
    Myosin_tail_1; Myosin tail

  2. NM_001389277.1 → NP_001376206.1  cingulin-like protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6AMD9, A6KEQ6, D4A3V5
    Related
    ENSRNOP00000103389.1, ENSRNOT00000165694.1
    Conserved Domains (1) summary
    pfam01576
    Location:617 → 1248
    Myosin_tail_1; Myosin tail

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    81154169..81305598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766286.4 → XP_008764508.1  cingulin-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_008764508.1

    UniProtKB/TrEMBL
    A0A8I6AMD9, A6KEQ6, D4A3V5
    Conserved Domains (1) summary
    pfam01576
    Location:617 → 1248
    Myosin_tail_1; Myosin tail

  2. XM_039081510.2 → XP_038937438.1  cingulin-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AMD9, A6KEQ6, D4A3V5
    Conserved Domains (1) summary
    pfam01576
    Location:617 → 1248
    Myosin_tail_1; Myosin tail

  3. XM_039081511.2 → XP_038937439.1  cingulin-like protein 1 isoform X2

    Conserved Domains (1) summary
    pfam01576
    Location:139 → 697
    Myosin_tail_1; Myosin tail
Nucleotide Protein Strain
Heading Accession and Version

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