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Snx33 sorting nexin 33 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315696, updated on 10-Jul-2024

Summary

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Official Symbol
Snx33provided by RGD
Official Full Name
sorting nexin 33provided by RGD
Primary source
RGD:1307898
See related
EnsemblRapid:ENSRNOG00000017382 AllianceGenome:RGD:1307898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sh3px3
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including cytoskeleton-dependent cytokinesis; plasma membrane tubulation; and regulation of protein localization to cell surface. Predicted to be located in cytoplasmic vesicle; cytosol; and membrane. Predicted to be extrinsic component of membrane. Orthologous to human SNX33 (sorting nexin 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 192.7), Lung (RPKM 148.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Snx33 in Genome Data Viewer
Location:
8q24
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66213133..66224926, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57315861..57328522, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (61584656..61596055, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480055 Neighboring gene ciliary microtubule associated protein 1C Neighboring gene transfer RNA proline (anticodon AGG) 41 Neighboring gene chondroitin sulfate proteoglycan 4 Neighboring gene ribosomal protein S15a like 7 Neighboring gene IMP U3 small nucleolar ribonucleoprotein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins. Wang JT, et al. PLoS One, 2010 Oct 29. PMID 21048941, Free PMC Article
  2. Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33. Dislich B, et al. Biochem J, 2011 Jan 1. PMID 20964629
  3. Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein. Zhang J, et al. J Biol Chem, 2009 Aug 7. PMID 19487689, Free PMC Article
  4. SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis. Ma MP, et al. J Cell Sci, 2012 Sep 15. PMID 22718350
  5. The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding. Heiseke A, et al. Traffic, 2008 Jul. PMID 18419754

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cleavage furrow formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cleavage furrow formation ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in macropinocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane tubulation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sorting nexin-33
Names
SH3 and PX domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127488.2 → NP_001120960.1  sorting nexin-33

    See identical proteins and their annotated locations for NP_001120960.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6J4R8, D4A3X7
    Related
    ENSRNOP00000023428.3, ENSRNOT00000023428.6
    Conserved Domains (3) summary
    cd07669
    Location:365 → 571
    BAR_SNX33; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 33
    cd11896
    Location:4 → 58
    SH3_SNX33; Src Homology 3 domain of Sorting Nexin 33
    cl02563
    Location:230 → 354
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  2. NM_001429233.1 → NP_001416162.1  sorting nexin-33

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6J4R8, D4A3X7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    66213133..66224926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243123.5 → XP_006243185.1  sorting nexin-33 isoform X1

    Conserved Domains (3) summary
    cd07669
    Location:365 → 571
    BAR_SNX33; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 33
    cd11896
    Location:4 → 58
    SH3_SNX33; Src Homology 3 domain of Sorting Nexin 33
    cl02563
    Location:230 → 354
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
Nucleotide Protein Strain
Heading Accession and Version

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