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Tnfaip8l3 TNF alpha induced protein 8 like 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315673, updated on 2-Nov-2024

Summary

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Official Symbol
Tnfaip8l3provided by RGD
Official Full Name
TNF alpha induced protein 8 like 3provided by RGD
Primary source
RGD:1311533
See related
AllianceGenome:RGD:1311533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311533
Summary
Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol transfer activity. Predicted to be involved in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process; phospholipid transport; and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human TNFAIP8L3 (TNF alpha induced protein 8 like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Uterus (RPKM 27.6), Lung (RPKM 25.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tnfaip8l3 in Genome Data Viewer
Location:
8q24
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (63309683..63351687, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (54413503..54455512, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (58599382..58648045, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094163 Neighboring gene ELMO domain containing 1 Neighboring gene uncharacterized LOC134480053 Neighboring gene uncharacterized LOC134480168 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC134480169 Neighboring gene uncharacterized LOC134480054

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identical expression profiling of human and murine TIPE3 protein reveals links to its functions. Cui J, et al. J Histochem Cytochem, 2015 Mar. PMID 25479791, Free PMC Article
  2. TIPE3 is the transfer protein of lipid second messengers that promote cancer. Fayngerts SA, et al. Cancer Cell, 2014 Oct 13. PMID 25242044, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol transfer activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor necrosis factor alpha-induced protein 8-like protein 3
Names
tumor necrosis factor, alpha-induced protein 8-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399312.1 → NP_001386241.1  tumor necrosis factor alpha-induced protein 8-like protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6J4K3, F1LX20
    Conserved Domains (1) summary
    pfam05527
    Location:43 → 197
    DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    63309683..63351687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082372.2 → XP_038938300.1  tumor necrosis factor alpha-induced protein 8-like protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYA0
    Conserved Domains (1) summary
    pfam05527
    Location:1 → 151
    DUF758; Domain of unknown function (DUF758)
Nucleotide Protein Strain
Heading Accession and Version

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