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Rbcn-3A Rabconnectin-3A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31557, updated on 2-Nov-2024

Summary

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Official Symbol
Rbcn-3Aprovided by FlyBase
Official Full Name
Rabconnectin-3Aprovided by FlyBase
Primary source
FLYBASE:FBgn0023458
Locus tag
Dmel_CG3585
See related
AllianceGenome:FB:FBgn0023458
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-X; CG3585; Dmel\CG3585; Dmx; DmX; FV10; rbcn3A; X
Summary
Involved in lumen formation, open tracheal system and vacuolar acidification. Predicted to be part of RAVE complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 71 and developmental and epileptic encephalopathy 81. Orthologous to human DMXL1 (Dmx like 1) and DMXL2 (Dmx like 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Rbcn-3A in Genome Data Viewer
Location:
5E1-5E3; 1-16 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6240745..6255487, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6134778..6149520, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene detonator Neighboring gene uncharacterized protein Neighboring gene schlank Neighboring gene Spliceosomal protein on the X Neighboring gene Josephin domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intracellular lumen formation in Drosophila proceeds via a novel subcellular compartment. Nikolova LS, et al. Development, 2015 Nov 15. PMID 26428009, Free PMC Article
  2. Enhanced nucleotide chemistry and toehold nanotechnology reveals lncRNA spreading on chromatin. Machyna M, et al. Nat Struct Mol Biol, 2020 Mar. PMID 32157249
  3. The new gene DmX from Drosophila melanogaster encodes a novel WD-repeat protein. Kraemer C, et al. Gene, 1998 Aug 31. PMID 9729422
  4. A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo. Couturier L, et al. J Cell Biol, 2014 Nov 10. PMID 25365996, Free PMC Article
  5. Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain. Wang M, et al. Nat Commun, 2021 Apr 7. PMID 33828096, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in lumen formation, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar acidification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RAVE complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rabconnectin-3A
Names
CG3585-PB
Rabconnectin-3alpha
Rbcn-3A-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6240745..6255487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132074.3 → NP_572302.2  Rabconnectin-3A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572302.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24593, Q9W425
    Conserved Domains (4) summary
    COG2319
    Location:3153 → 3373
    WD40; WD40 repeat [General function prediction only]
    pfam12234
    Location:1643 → 2134
    Rav1p_C; RAVE protein 1 C terminal
    sd00039
    Location:3203 → 3243
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:3158 → 3412
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24593 Q24593
Q9W425 Q9W425

Gene LinkOut

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