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Robo3 roundabout guidance receptor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315564, updated on 17-Aug-2024

Summary

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Official Symbol
Robo3provided by RGD
Official Full Name
roundabout guidance receptor 3provided by RGD
Primary source
RGD:1311018
See related
EnsemblRapid:ENSRNOG00000030016 AllianceGenome:RGD:1311018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to act upstream of or within axon guidance and neuron migration. Predicted to be located in axon. Orthologous to human ROBO3 (roundabout guidance receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 11.0), Kidney (RPKM 4.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Robo3 in Genome Data Viewer
Location:
8q22
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (45322323..45340466, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (37133542..37151674, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39892792..39923735, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 15 Neighboring gene transfer RNA proline (anticodon AGG) 64 Neighboring gene uncharacterized LOC120094115 Neighboring gene hepatic and glial cell adhesion molecule Neighboring gene roundabout guidance receptor 4 Neighboring gene uncharacterized LOC102549473 Neighboring gene Myb/SANT DNA binding domain containing 2 Neighboring gene endothelial cell adhesion molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Robo3.1A suppresses slit-mediated repulsion by triggering degradation of Robo2. Li L, et al. J Neurosci Res, 2014 Jul. PMID 24936616
  2. Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells. García M, et al. Biochim Biophys Acta, 2009 Nov. PMID 19747951
  3. Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion. Chen Z, et al. Neuron, 2008 May 8. PMID 18466743
  4. Expression of netrin-1, slit-1 and slit-3 but not of slit-2 after cerebellar and spinal cord lesions. Wehrle R, et al. Eur J Neurosci, 2005 Nov. PMID 16262652
  5. The slit receptor Rig-1/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons. Marillat V, et al. Neuron, 2004 Jul 8. PMID 15233918

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis.
    Title: Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells.
  2. Data show that cerebellofugal axons express Rig-1 (Robo3) before they reach the midline but not after the longitudinal turn.
    Title: Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in axon midline choice point recognition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
roundabout homolog 3
Names
roundabout, axon guidance receptor, homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394075.1 → NP_001381004.1  roundabout homolog 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6AJI9, A6KRL2, D3ZKA2
    Related
    ENSRNOP00000094407.1, ENSRNOT00000118811.2
    Conserved Domains (5) summary
    smart00408
    Location:465 → 528
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:264 → 343
    IG; Immunoglobulin
    smart00410
    Location:172 → 254
    IG_like; Immunoglobulin like
    cd00063
    Location:556 → 649
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:450 → 454
    Ig; Ig strand A [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    45322323..45340466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265426.1 → XP_063121496.1  roundabout homolog 3 isoform X1

    UniProtKB/TrEMBL
    A6KRL2, D3ZKA2

  2. XM_017595621.3 → XP_017451110.2  roundabout homolog 3 isoform X2

    UniProtKB/TrEMBL
    A6KRL2, D3ZKA2
    Conserved Domains (3) summary
    cd00063
    Location:556 → 649
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:348 → 352
    Ig; Ig strand A [structural motif]
    cl11960
    Location:348 → 445
    Ig; Immunoglobulin domain

  3. XM_063265427.1 → XP_063121497.1  roundabout homolog 3 isoform X3

  4. XM_063265428.1 → XP_063121498.1  roundabout homolog 3 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108135.1: Suppressed sequence

    Description
    NM_001108135.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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