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Btnd Biotinidase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31552, updated on 18-Sep-2024

Summary

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Official Symbol
Btndprovided by FlyBase
Official Full Name
Biotinidaseprovided by FlyBase
Primary source
FLYBASE:FBgn0029848
Locus tag
Dmel_CG3599
See related
AllianceGenome:FB:FBgn0029848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Btd; BTD; CG3599; CT12113; Dmel\CG3599
Summary
Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in histone biotinylation; peptidyl-lysine biotinylation; and response to heat. Is expressed in adult main segment of Malpighian tubule. Human ortholog(s) of this gene implicated in biotinidase deficiency. Orthologous to several human genes including BTD (biotinidase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Btnd in Genome Data Viewer
Location:
5E1-5E1; 1-16 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6217268..6219327, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6111301..6113360, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene vanin-like Neighboring gene uncharacterized protein Neighboring gene ER GDP-fucose transporter Neighboring gene spaghetti squash

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conservation of biotindase in mammals and identification of the putative biotinidase gene in Drosophila melanogaster. Swango KL, et al. Mol Genet Metab, 2001 Dec. PMID 11749055
  2. Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance. Camporeale G, et al. J Nutr, 2006 Nov. PMID 17056793, Free PMC Article
  3. Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model. Lohr KM, et al. Proc Natl Acad Sci U S A, 2020 Dec 29. PMID 33318181, Free PMC Article
  4. Metabolic disruption in Drosophila bang-sensitive seizure mutants. Fergestad T, et al. Genetics, 2006 Jul. PMID 16648587, Free PMC Article
  5. Metabolic pathways modulate the neuronal toxicity associated with fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Hum Mol Genet, 2019 Mar 15. PMID 30476102, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conserved seq in mammals, identification of putative gene for biotinidase in Drosophila
    Title: Conservation of biotindase in mammals and identification of the putative biotinidase gene in Drosophila melanogaster.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables biotinidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
biotinidase
Names
Btnd-PA
CG3599-PA
NP_572298.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6217268..6219327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132070.3 → NP_572298.1  biotinidase [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W430
    Related
    FBpp0070843
    Conserved Domains (1) summary
    cd07567
    Location:29 → 308
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W430 Q9W430

Gene LinkOut

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