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vanin-like vanin-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31551, updated on 28-Oct-2024

Summary

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Official Symbol
vanin-likeprovided by FlyBase
Official Full Name
vanin-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0040069
Locus tag
Dmel_CG32754
See related
AllianceGenome:FB:FBgn0040069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32754; CG3648; Dmel\CG32754; Vanin-like
Summary
Predicted to enable pantetheine hydrolase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in biotinidase deficiency. Orthologous to several human genes including BTD (biotinidase). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See vanin-like in Genome Data Viewer
Location:
5E1-5E1; 1-16 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6200188..6202559, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6094221..6096592, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Biotinidase Neighboring gene ER GDP-fucose transporter

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An ESTs description of the new Vanin gene family conserved from fly to human. Granjeaud S, et al. Immunogenetics, 1999 Oct. PMID 10501839
  2. CoA protects against the deleterious effects of caloric overload in Drosophila. Palanker Musselman L, et al. J Lipid Res, 2016 Mar. PMID 26805007, Free PMC Article
  3. Developmental ethanol exposure leads to dysregulation of lipid metabolism and oxidative stress in Drosophila. Logan-Garbisch T, et al. G3 (Bethesda), 2014 Nov 11. PMID 25387828, Free PMC Article
  4. The Impact of Microbiome and Microbiota-Derived Sodium Butyrate on Drosophila Transcriptome and Metabolome Revealed by Multi-Omics Analysis. Zhou F, et al. Metabolites, 2021 May 6. PMID 34066348, Free PMC Article
  5. Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. Huang J, et al. PNAS Nexus, 2023 Dec. PMID 38059264, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
enables pantetheine hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extrinsic component of membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
vanin-like
Names
CG32754-PA
pantetheine hydrolase
vanin-like-PA
NP_572297.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6200188..6202559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132069.3 → NP_572297.1  vanin-like [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572297.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFP1, Q9W431
    Related
    FBpp0070844
    Conserved Domains (1) summary
    cd07567
    Location:33 → 304
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NFP1.1 Q9NFP1

Gene LinkOut

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