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Arsa arylsulfatase A [ Rattus norvegicus (Norway rat) ]

Gene ID: 315222, updated on 4-Jan-2025

Summary

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Official Symbol
Arsaprovided by RGD
Official Full Name
arylsulfatase Aprovided by RGD
Primary source
RGD:1310381
See related
EnsemblRapid:ENSRNOG00000012953 AllianceGenome:RGD:1310381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables arylsulfatase activity. Involved in several processes, including response to estrogen; response to ethanol; and response to methylmercury. Located in acrosomal vesicle; endosome; and extracellular space. Is extrinsic component of external side of plasma membrane. Used to study hypothyroidism. Human ortholog(s) of this gene implicated in metachromatic leukodystrophy. Orthologous to human ARSA (arylsulfatase A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 217.6), Kidney (RPKM 146.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arsa in Genome Data Viewer
Location:
7q34
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122422971..122426971, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120542788..120547577, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130446644..130452632, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479955 Neighboring gene choline kinase beta Neighboring gene uncharacterized LOC134479956 Neighboring gene mitogen-activated protein kinase 8 interacting protein 2 Neighboring gene uncharacterized LOC120093826 Neighboring gene SH3 and multiple ankyrin repeat domains 3 Neighboring gene uncharacterized LOC108351527

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Studies on urinary arylsulphatase activity in vitamin A deficient rats. Srinivas L, et al. Int J Vitam Nutr Res, 1976. PMID 4403
  2. Ethanol decreases rat hepatic arylsulfatase A activity levels. Jean S, et al. Alcohol Clin Exp Res, 2006 Nov. PMID 17067361
  3. Purification of rat liver arylsulfatase A and its microheterogeneity assayed by crossed affinity-immunoelectrophoresis. Wójczyk B, et al. Acta Biochim Pol, 1992. PMID 1363453
  4. Rat sperm AS-A: subcellular localization in testis and epididymis and surface distribution in epididymal sperm. Ngernsoungnern A, et al. Cell Tissue Res, 2004 Nov. PMID 15503159
  5. Hypothyroidism in the adult rat causes brain region-specific biochemical dysfunction. Ahmed MT, et al. J Endocrinol, 1993 Aug. PMID 7901316

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC125207

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables arylsulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arylsulfatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables cerebroside-sulfatase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfuric ester hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estrogen IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to ethanol IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to methylmercury IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to nutrient IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to pH IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extrinsic component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arylsulfatase A
NP_001030105.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034933.3 → NP_001030105.2  arylsulfatase A precursor

    See identical proteins and their annotated locations for NP_001030105.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    F7FF93, Q32KK2, Q3KR80
    Related
    ENSRNOP00000017782.4, ENSRNOT00000017783.8
    Conserved Domains (2) summary
    COG3119
    Location:17 → 470
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:20 → 503
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    122422971..122426971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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