U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Usp30 Ubiquitin specific protease 30 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31519, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Usp30provided by FlyBase
Official Full Name
Ubiquitin specific protease 30provided by FlyBase
Primary source
FLYBASE:FBgn0029819
Locus tag
Dmel_CG3016
See related
AllianceGenome:FB:FBgn0029819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3016; Dmel\CG3016; dUSP30; Q9W462; USP30
Summary
Predicted to enable cysteine-type deubiquitinase activity. Involved in negative regulation of mitophagy. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol and nucleus. Is expressed in adult head. Orthologous to human USP30 (ubiquitin specific peptidase 30). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Usp30 in Genome Data Viewer
Location:
5C5-5C6; 1-14 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5877000..5879787, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5771033..5773820, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Glycosylphosphatidylinositol anchor attachment 1 Neighboring gene males absent on the first Neighboring gene long non-coding RNA:CR45668 Neighboring gene uncharacterized protein Neighboring gene Actin 5C

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mitochondrial dynamics and mitophagy in Parkinson's disease: A fly point of view. Von Stockum S, et al. Neurobiol Dis, 2016 Jun. PMID 26550693
  2. Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila. Cornelissen T, et al. Elife, 2018 May 29. PMID 29809156, Free PMC Article
  3. FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo. Sanchez-Martinez A, et al. PLoS Biol, 2023 Aug. PMID 37535686, Free PMC Article
  4. Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models. Au WH, et al. Life Sci Alliance, 2024 Sep. PMID 38906677, Free PMC Article
  5. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Bingol B, et al. Nature, 2014 Jun 19. PMID 24896179

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type deubiquitinase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of mitophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K11-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K6-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquitin specific protease 30
Names
CG3016-PA
CG3016-PB
Usp30-PA
Usp30-PB
ubiquitin specific peptidase 30
NP_001284912.1
NP_572274.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5877000..5879787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132046.3 → NP_572274.1  ubiquitin specific protease 30, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572274.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W462
    Related
    FBpp0070793
    Conserved Domains (3) summary
    cd02662
    Location:323 → 548
    Peptidase_C19F; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:39 → 139
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:304 → 547
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. NM_001297983.1 → NP_001284912.1  ubiquitin specific protease 30, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284912.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W462
    Conserved Domains (3) summary
    cd02662
    Location:323 → 548
    Peptidase_C19F; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:39 → 139
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:304 → 547
    UCH; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W462.1 Q9W462

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous