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Naga alpha-N-acetylgalactosaminidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 315165, updated on 2-May-2024

Summary

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Official Symbol
Nagaprovided by RGD
Official Full Name
alpha-N-acetylgalactosaminidaseprovided by RGD
Primary source
RGD:1306025
See related
Ensembl:ENSRNOG00000008064 AllianceGenome:RGD:1306025
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable alpha-N-acetylgalactosaminidase activity; alpha-galactosidase activity; and protein homodimerization activity. Predicted to be involved in several processes, including glycoside catabolic process; glycosylceramide catabolic process; and oligosaccharide metabolic process. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to human NAGA (alpha-N-acetylgalactosaminidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 157.7), Lung (RPKM 124.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Naga in Genome Data Viewer
Location:
7q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115726438..115735494, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113846358..113855430, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123563047..123572074, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351520 Neighboring gene septin 3 Neighboring gene WBP2 N-terminal like Neighboring gene uncharacterized LOC134479948 Neighboring gene PH domain containing endocytic trafficking adaptor 2 Neighboring gene single-pass membrane protein with aspartate-rich tail 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases. Clark NE, et al. J Mol Biol, 2009 Oct 23. PMID 19683538, Free PMC Article
  2. The molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes angiokeratoma corporis diffusum with glycopeptiduria. Wang AM, et al. J Clin Invest, 1994 Aug. PMID 8040340, Free PMC Article
  3. Schindler disease: the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy. Wang AM, et al. J Clin Invest, 1990 Nov. PMID 2243144, Free PMC Article
  4. Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts. Asfaw B, et al. J Lipid Res, 1998 Sep. PMID 9741689
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-N-acetylgalactosaminidase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-N-acetylgalactosaminidase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-N-acetylgalactosaminidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alpha-galactosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in carbohydrate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycolipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycoside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-N-acetylgalactosaminidase
Names
N-acetyl galactosaminidase, alpha
alpha-galactosidase B
NP_001012120.1
XP_006242149.1
XP_006242150.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012120.1 → NP_001012120.1  alpha-N-acetylgalactosaminidase precursor

    See identical proteins and their annotated locations for NP_001012120.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082084
    UniProtKB/Swiss-Prot
    Q66H12
    UniProtKB/TrEMBL
    A0A8I6B4W8, A6HT60
    Conserved Domains (1) summary
    cl07893
    Location:25 → 394
    AmyAc_family; Alpha amylase catalytic domain family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    115726438..115735494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242088.5 → XP_006242150.1  alpha-N-acetylgalactosaminidase isoform X1

    See identical proteins and their annotated locations for XP_006242150.1

    UniProtKB/Swiss-Prot
    Q66H12
    UniProtKB/TrEMBL
    A0A8I6B4W8, A6HT60
    Conserved Domains (1) summary
    cl07893
    Location:25 → 394
    AmyAc_family; Alpha amylase catalytic domain family

  2. XM_006242087.5 → XP_006242149.1  alpha-N-acetylgalactosaminidase isoform X1

    See identical proteins and their annotated locations for XP_006242149.1

    UniProtKB/Swiss-Prot
    Q66H12
    UniProtKB/TrEMBL
    A0A8I6B4W8, A6HT60
    Related
    ENSRNOP00000060590.1
    Conserved Domains (1) summary
    cl07893
    Location:25 → 394
    AmyAc_family; Alpha amylase catalytic domain family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66H12.1 GenPept UniProtKB/Swiss-Prot:Q66H12

Gene LinkOut

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