Osr2 odd-skipped related transciption factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Osr2provided by RGD
Official Full Name: odd-skipped related transciption factor 2provided by RGD
Primary source: RGD:1305812
See related: EnsemblRapid:ENSRNOG00000011136 AllianceGenome:RGD:1305812
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including animal organ development; osteoblast proliferation; and regulation of gene expression. Predicted to act upstream of or within embryonic limb morphogenesis and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human OSR2 (odd-skipped related transciption factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Uterus (RPKM 85.9), Testes (RPKM 29.5) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (68372500..68380195)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (66487841..66495003)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (74047820..74055096)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH137384 (e-PCR)
- UniSTS:219472

BI289743 (e-PCR)
- UniSTS:246933

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in embryo development	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryo development ending in birth or egg hatching	ISO Inferred from Sequence Orthology more info
involved_in embryo development ending in birth or egg hatching	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal joint development	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal joint morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal limb joint morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in eyelid development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in eyelid development in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info
involved_in head development	ISO Inferred from Sequence Orthology more info
involved_in mesonephros development	ISO Inferred from Sequence Orthology more info
involved_in mesonephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in metanephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in middle ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in middle ear morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gastrulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in pronephros development	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in urogenital system development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein odd-skipped-related 2

Names: odd-skipped related 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012118.1 → NP_001012118.1 protein odd-skipped-related 2

See identical proteins and their annotated locations for NP_001012118.1

Status: PROVISIONAL

Source sequence(s)

BC079211

UniProtKB/Swiss-Prot

Q6AY34

Conserved Domains (4) summary

sd00017
Location:174 → 194

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:172 → 194

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:186 → 211

zf-H2C2_2; Zinc-finger double domain

cl14876
Location:18 → 124

Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

68372500..68380195

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594862.3 → XP_017450351.1 protein odd-skipped-related 2 isoform X1

UniProtKB/TrEMBL

A6HR12

Related

ENSRNOP00000014879.5, ENSRNOT00000014879.8

Conserved Domains (3) summary

COG5048
Location:251 → 312

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:174 → 194

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:186 → 211

zf-H2C2_2; Zinc-finger double domain