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PGAP1 Post-GPI attachment to proteins 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31487, updated on 2-Nov-2024

Summary

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Official Symbol
PGAP1provided by FlyBase
Official Full Name
Post-GPI attachment to proteins 1provided by FlyBase
Primary source
FLYBASE:FBgn0029789
Locus tag
Dmel_CG3160
See related
AllianceGenome:FB:FBgn0029789
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3160; Dmel\CG3160
Summary
Predicted to enable phosphatidylinositol deacylase activity. Predicted to be involved in GPI anchor biosynthetic process and positive regulation of ER to Golgi vesicle-mediated transport. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Orthologous to human PGAP1 (post-GPI attachment to proteins inositol deacylase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See PGAP1 in Genome Data Viewer
Location:
5A12-5A13; 1-12 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5685253..5689473, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5579286..5583506, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44958 Neighboring gene Gustatory receptor 5a Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45525 Neighboring gene crossveinless Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila suzukii: the genetic footprint of a recent, worldwide invasion. Adrion JR, et al. Mol Biol Evol, 2014 Dec. PMID 25158796, Free PMC Article
  2. Female site-specific transposase-induced recombination: a high-efficiency method for fine mapping mutations on the X chromosome in Drosophila. Marcus JM. Genetics, 2003 Feb. PMID 12618398, Free PMC Article
  3. crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling. Vilmos P, et al. EMBO Rep, 2005 Mar. PMID 15711536, Free PMC Article
  4. The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing. Shimmi O, et al. Dev Biol, 2005 Jun 1. PMID 15936330
  5. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol deacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol deacylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ER to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Post-GPI attachment to proteins 1
Names
CG3160-PA
PGAP1-PA
NP_572245.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5685253..5689473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132017.2 → NP_572245.1  Post-GPI attachment to proteins 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572245.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T8Q8, Q9W495
    Related
    FBpp0070812
    Conserved Domains (1) summary
    pfam07819
    Location:79 → 324
    PGAP1; PGAP1-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W495.3 Q9W495

Gene LinkOut

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