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Acss3 acyl-CoA synthetase short-chain family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314800, updated on 2-Nov-2024

Summary

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Official Symbol
Acss3provided by RGD
Official Full Name
acyl-CoA synthetase short-chain family member 3provided by RGD
Primary source
RGD:1307051
See related
EnsemblRapid:ENSRNOG00000004448 AllianceGenome:RGD:1307051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307051
Summary
Enables acetate-CoA ligase activity; medium-chain fatty acid-CoA ligase activity; and propionate-CoA ligase activity. Predicted to be involved in lipid metabolic process. Located in mitochondrial matrix. Orthologous to human ACSS3 (acyl-CoA synthetase short chain family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 449.1), Liver (RPKM 411.1) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Acss3 in Genome Data Viewer
Location:
7q21
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (44127725..44336707, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (42241261..42450209, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (49047022..49250953, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene methyltransferase like 25 Neighboring gene coiled-coil domain containing 59 Neighboring gene uncharacterized LOC134479682 Neighboring gene PTPRF interacting protein alpha 2 Neighboring gene sulfotransferase 1C2 pseudogene Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134479592

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of rat acss3 and characterization of mammalian propionyl-CoA synthetase in the liver mitochondrial matrix. Yoshimura Y, et al. J Biochem, 2017 Mar 1. PMID 28003429
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results suggested that ACSS3 is a liver mitochondrial matrix enzyme with high affinity to propionic acid, and its expression level is upregulated under ketogenic conditions.
    Title: Molecular cloning of rat acss3 and characterization of mammalian propionyl-CoA synthetase in the liver mitochondrial matrix.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables medium-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables propionate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables propionate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables propionate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acyl-CoA synthetase short-chain family member 3, mitochondrial
Names
acetate--CoA ligase 3
propionate--CoA ligase
NP_001101561.1
NP_001401870.1
XP_006241365.1
XP_038935035.1
XP_038935036.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108091.2 → NP_001101561.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001101561.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6IGC2, D3ZGU2
    Related
    ENSRNOP00000062459.1, ENSRNOT00000066975.3
    Conserved Domains (1) summary
    cl17068
    Location:68 → 479
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. NM_001414941.1 → NP_001401870.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    A0A0G2K047
    Related
    ENSRNOP00000071300.1, ENSRNOT00000082141.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    44127725..44336707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079107.2 → XP_038935035.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd05967
    Location:1 → 571
    PrpE; Propionyl-CoA synthetase (PrpE)

  2. XM_006241303.5 → XP_006241365.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006241365.1

    Conserved Domains (1) summary
    cd05967
    Location:1 → 571
    PrpE; Propionyl-CoA synthetase (PrpE)

  3. XM_039079108.2 → XP_038935036.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl17068
    Location:58 → 447
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0G2K047.1 GenPept UniProtKB/Swiss-Prot:A0A0G2K047

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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