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Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314785, updated on 2-Nov-2024

Summary

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Official Symbol
Tmtc3provided by RGD
Official Full Name
transmembrane O-mannosyltransferase targeting cadherins 3provided by RGD
Primary source
RGD:1306351
See related
EnsemblRapid:ENSRNOG00000006749 AllianceGenome:RGD:1306351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306351
Summary
Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in positive regulation of proteasomal protein catabolic process; protein O-linked mannosylation; and response to endoplasmic reticulum stress. Predicted to act upstream of or within several processes, including lung development; muscle cell development; and post-embryonic development. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in lissencephaly 8. Orthologous to human TMTC3 (transmembrane O-mannosyltransferase targeting cadherins 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 112.9), Heart (RPKM 91.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmtc3 in Genome Data Viewer
Location:
7q21
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (37151456..37196550, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (35264886..35310010, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (40171957..40217056, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene small nucleolar RNA SNORA48 Neighboring gene centrosomal protein 290 Neighboring gene transfer RNA proline (anticodon GGG) 7 Neighboring gene RNA 5'-phosphate and 3'-OH ligase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response. Racapé M, et al. PLoS One, 2011. PMID 21603654, Free PMC Article
  2. Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins. Larsen ISB, et al. Proc Natl Acad Sci U S A, 2017 Oct 17. PMID 28973932, Free PMC Article
  3. mSmile is necessary for bronchial smooth muscle and alveolar myofibroblast development. Yun EJ, et al. Anat Rec (Hoboken), 2012 Jan. PMID 21956870
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bud outgrowth involved in lung branching ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lung alveolus development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within muscle cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein O-mannosyl-transferase TMTC3
Names
transmembrane and TPR repeat-containing protein 3
transmembrane and tetratricopeptide repeat containing 3
NP_001129330.1
XP_038935012.1
XP_063119535.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135858.2 → NP_001129330.1  protein O-mannosyl-transferase TMTC3

    See identical proteins and their annotated locations for NP_001129330.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6IG92, D3ZUJ8
    Related
    ENSRNOP00000037617.6, ENSRNOT00000029045.6
    Conserved Domains (5) summary
    COG0457
    Location:400 → 688
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:535 → 562
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:602 → 635
    TPR_1; Tetratricopeptide repeat
    pfam08409
    Location:263 → 336
    DUF1736; Domain of unknown function (DUF1736)
    pfam13414
    Location:672 → 738
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    37151456..37196550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079084.2 → XP_038935012.1  protein O-mannosyl-transferase TMTC3 isoform X1

    Conserved Domains (4) summary
    TIGR02917
    Location:204 → 571
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:299 → 326
    TPR; TPR repeat [structural motif]
    pfam08409
    Location:28 → 100
    DUF1736; Domain of unknown function (DUF1736)
    cl28891
    Location:563 → 605
    ParB_N_Srx; ParB N-terminal domain and sulfiredoxin protein-related families

  2. XM_063263465.1 → XP_063119535.1  protein O-mannosyl-transferase TMTC3 isoform X2

RNA

  1. XR_010052970.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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