ovo ovo [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ovoprovided by FlyBase
Official Full Name: ovoprovided by FlyBase
Primary source: FLYBASE:FBgn0003028
Locus tag: Dmel_CG6824
See related: AllianceGenome:FB:FBgn0003028
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15467; CG6824; Dmel\CG6824; Fs(1)K1103; fs(1)K1237; Fs(1)K1237; Fs(1)K155; fs(1)M1; fs(1)M38; Ovo; OVO; Ovo-D; ovo/shavenbaby; ovo/svb; ovoD; Shv; svb; Svb; svb/ovo; Svb/Ovo
Summary: Enables sequence-specific double-stranded DNA binding activity and transcription coactivator binding activity. Involved in several processes, including adult feeding behavior; regionalization; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including denticle field anlage; epithelium; germline cell; organism subdivision; and trichome field. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to several human genes including OVOL1 (ovo like transcriptional repressor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 4E2-4E2; 1-10 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5048273..5070929)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4942306..4964962)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OVO positively regulates essential maternal pathways by binding near the transcriptional start sites in the Drosophila female germline.
Title: OVO positively regulates essential maternal pathways by binding near the transcriptional start sites in the Drosophila female germline.
Here, the authors show that a molecular complex identified in Drosophila epidermal differentiation, comprising Mlpt peptides, ubiquitin-ligase Ubr3 and transcription factor Shavenbaby (Svb), represents an ancient developmental module required for early insect embryo patterning.
Title: The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning.
Transcription sites of the full svb cis-regulatory region inserted into a different chromosome colocalized with the svb locus, increasing Ubx concentration, the transcriptional output of svb, and partially rescuing the phenotype.
Title: Multi-enhancer transcriptional hubs confer phenotypic robustness.
Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis
Title: Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis.
Co-expressing ectopic SoxN with svb rescued diverse denticle morphologies. Conversely, removing SoxN activity eliminated the residual denticles found in svb mutant embryos. Furthermore, several known Svb target genes are also activated by SoxN, and we have discovered two novel target genes of SoxN that are expressed in denticle-producing cells and that are regulated independently of Svb.
Title: SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila.
Report the high-resolution functional dissection of a robust enhancer of the shavenbaby gene that has contributed to morphological evolution. We found that robustness is encoded by many binding sites for the transcriptional activator Arrowhead and that, during evolution, some of these activator sites were lost, weakening enhancer activity.
Title: Evolved Repression Overcomes Enhancer Robustness.
Hox protein Ultrabithorax (Ubx) in complex with its cofactor Extradenticle (Exd) bound specifically to clusters of very low affinity sites in enhancers of the shavenbaby gene of Drosophila. These low affinity sites conferred specificity for Ubx binding in vivo, but multiple clustered sites were required for robust expression when embryos developed in variable environments.
Title: Low affinity binding site clusters confer hox specificity and regulatory robustness.
Multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo.
Title: The structure and evolution of cis-regulatory regions: the shavenbaby story.
study shows peptides of 11 to 32 amino acids encoded by polished rice(pri)sORF gene control epidermal differentiation by modifying Shavenbaby (Svb); Pri peptides trigger amino-terminal truncation of Svb which converts Svb from a repressor to an activator
Title: Small peptides switch the transcriptional activity of Shavenbaby during Drosophila embryogenesis.
Results show that the embryonic expression of dsc73 requires Shavenbaby, a transcription factor regulating cuticle formation.
Title: Expression of the Drosophila secreted cuticle protein 73 (dsc73) requires Shavenbaby.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adult feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line sex determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germ-line sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg joint morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-sensory hair organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transposition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ovo

Names: CG6824-PA; CG6824-PB; CG6824-PC; CG6824-PD; CG6824-PE; ovo-PA; ovo-PB; ovo-PC; ovo-PD; ovo-PE; ovo/shaven-baby; shaven baby; shavenbaby

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

5048273..5070929

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169202.2 → NP_001162673.1 ovo, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162673.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JJE5, O02468, P51521, Q2PE28, Q8MPN4, Q8SX56, Q8T8L9, Q9W4F0, Q9W4F1, Q9W4F2, Q9XZU4, Q9Y046

Conserved Domains (2) summary

sd00017
Location:1199 → 1219

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:1239 → 1264

zf-H2C2_2; Zinc-finger double domain
NM_167026.4 → NP_726971.1 ovo, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726971.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JJE5, O02468, P51521, Q2PE28, Q8MPN4, Q8SX56, Q8T8L9, Q9W4F0, Q9W4F1, Q9W4F2, Q9XZU4, Q9Y046

Related

FBpp0070706

Conserved Domains (2) summary

sd00017
Location:1199 → 1219

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:1239 → 1264

zf-H2C2_2; Zinc-finger double domain
NM_167027.4 → NP_726972.1 ovo, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726972.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P51521

Related

FBpp0070707

Conserved Domains (2) summary

sd00017
Location:1070 → 1090

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:1110 → 1135

zf-H2C2_2; Zinc-finger double domain
NM_080338.5 → NP_525077.2 ovo, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_525077.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P51521

Related

FBpp0070708

Conserved Domains (2) summary

sd00017
Location:823 → 843

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:863 → 888

zf-H2C2_2; Zinc-finger double domain
NM_001038742.3 → NP_001033831.1 ovo, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001033831.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P51521

Conserved Domains (2) summary

sd00017
Location:876 → 896

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:916 → 941

zf-H2C2_2; Zinc-finger double domain