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Mdga2 MAM domain containing glycosylphosphatidylinositol anchor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314180, updated on 2-Nov-2024

Summary

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Official Symbol
Mdga2provided by RGD
Official Full Name
MAM domain containing glycosylphosphatidylinositol anchor 2provided by RGD
Primary source
RGD:735131
See related
EnsemblRapid:ENSRNOG00000000618 AllianceGenome:RGD:735131
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mamdc1
Summary
Involved in regulation of synapse maturation and spinal cord motor neuron differentiation. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 58.5), Testes (RPKM 14.2) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mdga2 in Genome Data Viewer
Location:
6q24
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (90482687..91346784, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (84746422..85608640, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (88442620..89292454, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479393 Neighboring gene U2 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134479395 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene mitochondrial transcription termination factor 1, pseudogene 4 Neighboring gene small nucleolar RNA, H/ACA box 32 Neighboring gene U2 spliceosomal RNA Neighboring gene ribosomal protein L11, pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior. Toledo A, et al. Elife, 2022 May 9. PMID 35532105, Free PMC Article
  2. Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism-Linked Excitatory Synaptic Suppressor MDGA2. Connor SA, et al. Neuron, 2016 Sep 7. PMID 27608760
  3. A chimaeric mouse model for autosomal-dominant polycystic kidney disease. Boulter CA, et al. Contrib Nephrol, 1992. PMID 1633717
  4. Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex. Moore JM, et al. PLoS One, 2014. PMID 25162227, Free PMC Article
  5. MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development. Lee K, et al. Proc Natl Acad Sci U S A, 2013 Jan 2. PMID 23248271, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.
    Title: MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within motor behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuromuscular process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pattern specification process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synapse maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in spinal cord motor neuron differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
Names
MAM domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199269.1 → NP_954890.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 2 precursor

    See identical proteins and their annotated locations for NP_954890.1

    Status: PROVISIONAL

    Source sequence(s)
    AY371924
    UniProtKB/Swiss-Prot
    P60756
    UniProtKB/TrEMBL
    A0A0H2UH93
    Related
    ENSRNOP00000000767.6, ENSRNOT00000000767.7
    Conserved Domains (6) summary
    cd06263
    Location:741 → 912
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    cd00096
    Location:355 → 427
    Ig; Immunoglobulin domain
    smart00408
    Location:256 → 317
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:48 → 128
    IG_like; Immunoglobulin like
    pfam00629
    Location:741 → 914
    MAM; MAM domain, meprin/A5/mu
    pfam13895
    Location:543 → 618
    Ig_2; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    90482687..91346784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764688.4 → XP_008762910.2  MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0H2UH93, A0A8I6AD32
    Related
    ENSRNOP00000092110.1, ENSRNOT00000116494.2
    Conserved Domains (6) summary
    smart00408
    Location:256 → 317
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:48 → 128
    IG; Immunoglobulin
    pfam00629
    Location:748 → 920
    MAM; MAM domain, meprin/A5/mu
    pfam13927
    Location:441 → 518
    Ig_3; Immunoglobulin domain
    cd00096
    Location:461 → 468
    Ig; Ig strand B [structural motif]
    cl11960
    Location:349 → 424
    Ig; Immunoglobulin domain

  2. XM_039112248.2 → XP_038968176.1  MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0H2UH93
    Related
    ENSRNOP00000100044.1, ENSRNOT00000153837.1
    Conserved Domains (6) summary
    smart00408
    Location:256 → 317
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:48 → 128
    IG; Immunoglobulin
    pfam00629
    Location:748 → 893
    MAM; MAM domain, meprin/A5/mu
    pfam13927
    Location:441 → 518
    Ig_3; Immunoglobulin domain
    cd00096
    Location:461 → 468
    Ig; Ig strand B [structural motif]
    cl11960
    Location:349 → 424
    Ig; Immunoglobulin domain

RNA

  1. XR_001838168.3 RNA Sequence

  2. XR_001838167.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60756.1 GenPept UniProtKB/Swiss-Prot:P60756

Gene LinkOut

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