U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

E2f6 E2F transcription factor 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313978, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
E2f6provided by RGD
Official Full Name
E2F transcription factor 6provided by RGD
Primary source
RGD:631412
See related
EnsemblRapid:ENSRNOG00000004449 AllianceGenome:RGD:631412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to contribute to DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be located in nucleoplasm. Predicted to be part of MLL1 complex and RNA polymerase II transcription regulator complex. Orthologous to human E2F6 (E2F transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 503.6), Heart (RPKM 498.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See E2f6 in Genome Data Viewer
Location:
6q16
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (45320993..45337437)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (39592224..39608685)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (42092513..42108692)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene lipin 1 Neighboring gene neurotensin receptor 2 Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene Rho-associated coiled-coil containing protein kinase 2 Neighboring gene solute carrier family 66 member 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterisation and regulation of E2F-6 and E2F-6b in the rat heart: a potential target for myocardial regeneration? Movassagh M, et al. J Pharm Pharmacol, 2006 Jan. PMID 16393466
  2. Analysis of the relevance of e2fs and their target genes with rat liver regeneration. Dong HM, et al. Indian J Gastroenterol, 2008 Jan-Feb. PMID 18541936
  3. E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Trimarchi JM, et al. Proc Natl Acad Sci U S A, 1998 Mar 17. PMID 9501179, Free PMC Article
  4. A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. Giangrande PH, et al. Genes Dev, 2004 Dec 1. PMID 15574595, Free PMC Article
  5. PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors. Deshpande AM, et al. Oncogene, 2007 Mar 15. PMID 17001316, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E2F transcription factor genes and their 34 target genes have a role in liver regeneration.
    Title: Analysis of the relevance of e2fs and their target genes with rat liver regeneration.
  2. isolation and characterization of E2F6 and splice variant named E2F6b in cardiomyocytes as down-reg. in neonate and up-reg. in development of cardiomyocyte hypertrophy
    Title: Characterisation and regulation of E2F-6 and E2F-6b in the rat heart: a potential target for myocardial regeneration?
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transcription factor E2F6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100717.2 → NP_001094187.1  transcription factor E2F6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    D4ACR8, Q80ZB0
    Related
    ENSRNOP00000057241.5, ENSRNOT00000060499.6
    Conserved Domains (2) summary
    cd14660
    Location:139 → 239
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:65 → 128
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    45320993..45337437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112208.2 → XP_038968136.1  transcription factor E2F6 isoform X2

    Conserved Domains (2) summary
    cd14660
    Location:87 → 187
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:13 → 76
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  2. XM_039112207.2 → XP_038968135.1  transcription factor E2F6 isoform X1

    UniProtKB/TrEMBL
    D4ACR8
    Conserved Domains (2) summary
    cd14660
    Location:104 → 204
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:30 → 93
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  3. XM_006239913.5 → XP_006239975.1  transcription factor E2F6 isoform X1

    UniProtKB/TrEMBL
    D4ACR8
    Related
    ENSRNOP00000076801.1, ENSRNOT00000096820.2
    Conserved Domains (2) summary
    cd14660
    Location:104 → 204
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:30 → 93
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous