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peb pebbled [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31391, updated on 2-Nov-2024

Summary

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Official Symbol
pebprovided by FlyBase
Official Full Name
pebbledprovided by FlyBase
Primary source
FLYBASE:FBgn0003053
Locus tag
Dmel_CG12212
See related
AllianceGenome:FB:FBgn0003053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-4Cg; CG12212; Dmel\CG12212; EG:66A1.1; EP55; Hin; Hind; hnd; hnt; Hnt; HNT; Peb; PEB
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell morphogenesis involved in neuron differentiation; embryonic development via the syncytial blastoderm; and positive regulation of cell-cell adhesion. Located in nucleus and polytene chromosome. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; peripheral nervous system; presumptive embryonic/larval system; and tracheal primordium. Orthologous to human RREB1 (ras responsive element binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See peb in Genome Data Viewer
Location:
4C10-4C10; 1-8 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4617564..4627206)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4511597..4521239)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR32773 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Alstrom syndrome 1b Neighboring gene Alstrom syndrome 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of hindsight in sensory organ precursors is associated with a transformation of campaniform sensilla to microchaetae in the Drosophila wing. Szablewski K, et al. MicroPubl Biol, 2019 May 20. PMID 32550447, Free PMC Article
  2. A Method for Rapid Selection of Randomly Induced Mutations in a Gene of Interest Using CRISPR/Cas9 Mediated Activation of Gene Expression. Ng WA, et al. G3 (Bethesda), 2020 Jun 1. PMID 32312838, Free PMC Article
  3. Clonal dominance in excitable cell networks. Alsous JI, et al. Nat Phys, 2021 Dec. PMID 35242199, Free PMC Article
  4. Asymmetric segregation of Numb and Prospero during cell division. Knoblich JA, et al. Nature, 1995 Oct 19. PMID 7566172
  5. ovo, a Drosophila gene required for ovarian development, is specifically expressed in the germline and shares most of its coding sequences with shavenbaby, a gene involved in embryo patterning. Mével-Ninio M, et al. Mech Dev, 1995 Jan. PMID 7748792

See all (277) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hnt is the positive regulator of EGFR signaling.
    Title: A Functional Analysis of the Drosophila Gene hindsight: Evidence for Positive Regulation of EGFR Signaling.
  2. Here, the authors identify a zinc-finger transcription factor Hindsight (Hnt) as the first transcription factor regulating follicle's competency for ovulation in Drosophila.
    Title: The zinc-finger transcription factor Hindsight regulates ovulation competency of Drosophila follicles.
  3. Peb is expressed in developing and mature sensory neurons, suggesting it is required to establish or maintain their competence to undergo axon death.
    Title: Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration.
  4. HNT regulates R-cell axon targeting through transcriptional regulation of multiple genes
    Title: Hindsight regulates photoreceptor axon targeting through transcriptional control of jitterbug/Filamin and multiple genes involved in axon guidance in Drosophila.
  5. Thus HNT and c are functional homologs at the level of DNA binding, transcriptional regulation and developmental control
    Title: Drosophila Hindsight and mammalian RREB-1 are evolutionarily conserved DNA-binding transcriptional attenuators.
  6. Hindsight functions in the determined R1/R6 precursor cells to allow Delta transcription to reach high enough levels at the right time to induce the cone-cell determinants Prospero and D-Pax2 in neighboring cells
    Title: Hindsight modulates Delta expression during Drosophila cone cell induction.
  7. essential to reduce cell-cell adhesion when epithelial cells within an interconnected group undergo dynamic changes in cell shape
    Title: Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1.
  8. Our studies suggest that Hindsight bridges the two antagonistic pathways, Notch and Hedgehog, in the temporal regulation of follicle-cell proliferation and differentiation.
    Title: Hindsight mediates the role of notch in suppressing hedgehog signaling and cell proliferation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in amnioserosa maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of ommatidial planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-band shortening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in head involution NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in maintenance of epithelial integrity, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ommatidial rotation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in photoreceptor cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in photoreceptor cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of epithelial cell-cell adhesion involved in epithelium migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of homophilic cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wing disc dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pebbled
Names
CG12212-PA
CG12212-PB
hindsight
peb-PA
peb-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4617564..4627206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014722.2 → NP_001014722.1  pebbled, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014722.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3V3, Q9W4J1
    Conserved Domains (4) summary
    COG3827
    Location:1299 → 1430
    PopZ; Cell pole-organizing protein PopZ [Cell cycle control, cell division, chromosome partitioning]
    sd00017
    Location:252 → 272
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1453 → 1473
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1718 → 1742
    zf-H2C2_2; Zinc-finger double domain

  2. NM_057326.5 → NP_476674.3  pebbled, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476674.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3V3, Q9W4J1
    Related
    FBpp0070648
    Conserved Domains (4) summary
    COG3827
    Location:1299 → 1430
    PopZ; Cell pole-organizing protein PopZ [Cell cycle control, cell division, chromosome partitioning]
    sd00017
    Location:252 → 272
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1453 → 1473
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1718 → 1742
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46205 O46205
Q7K3V3 Q7K3V3
Q9W4J1 Q9W4J1

Gene LinkOut

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