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Rasgrp3 RAS guanyl releasing protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313874, updated on 2-Nov-2024

Summary

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Official Symbol
Rasgrp3provided by RGD
Official Full Name
RAS guanyl releasing protein 3provided by RGD
Primary source
RGD:1304612
See related
EnsemblRapid:ENSRNOG00000032703 AllianceGenome:RGD:1304612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase regulator activity and enzyme binding activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RASGRP3 (RAS guanyl releasing protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 171.3), Lung (RPKM 121.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rasgrp3 in Genome Data Viewer
Location:
6q12-q13
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (25647386..25745952, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (19895361..19993945, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (21072634..21171619, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A, pseudogene 13 Neighboring gene family with sequence similarity 98, member A Neighboring gene ribosomal protein L32, pseudogene 18 Neighboring gene uncharacterized LOC120103479 Neighboring gene latent transforming growth factor beta binding protein 1 Neighboring gene 40S ribosomal protein S18 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interactions between drebrin and Ras regulate dendritic spine plasticity. Biou V, et al. Eur J Neurosci, 2008 Jun. PMID 18588530
  2. RasGRP3 mediates phorbol ester-induced, protein kinase C-independent exocytosis. Ozaki N, et al. Biochem Biophys Res Commun, 2005 Apr 8. PMID 15737652
  3. Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. Yang HC, et al. PLoS One, 2009. PMID 19421330, Free PMC Article
  4. Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Aiba Y, et al. Proc Natl Acad Sci U S A, 2004 Nov 23. PMID 15545601, Free PMC Article
  5. Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling. Regier DS, et al. Proc Natl Acad Sci U S A, 2005 May 24. PMID 15894621, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of guanyl-nucleotide exchange factor complex ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras guanyl-releasing protein 3
Names
RAS guanyl releasing protein 3 (calcium and DAG-regulated)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399544.1 → NP_001386473.1  ras guanyl-releasing protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A0G2KAU4
    Related
    ENSRNOP00000051116.4, ENSRNOT00000051239.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    25647386..25745952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261852.1 → XP_063117922.1  ras guanyl-releasing protein 3 isoform X1

  2. XM_063261857.1 → XP_063117927.1  ras guanyl-releasing protein 3 isoform X1

  3. XM_063261858.1 → XP_063117928.1  ras guanyl-releasing protein 3 isoform X1

  4. XM_063261853.1 → XP_063117923.1  ras guanyl-releasing protein 3 isoform X1

  5. XM_063261856.1 → XP_063117926.1  ras guanyl-releasing protein 3 isoform X1

  6. XM_063261859.1 → XP_063117929.1  ras guanyl-releasing protein 3 isoform X1

  7. XM_063261854.1 → XP_063117924.1  ras guanyl-releasing protein 3 isoform X1

  8. XM_063261855.1 → XP_063117925.1  ras guanyl-releasing protein 3 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108009.2: Suppressed sequence

    Description
    NM_001108009.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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