U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Qpct glutaminyl-peptide cyclotransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 313837, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Qpctprovided by RGD
Official Full Name
glutaminyl-peptide cyclotransferaseprovided by RGD
Primary source
RGD:1562284
See related
EnsemblRapid:ENSRNOG00000005705 AllianceGenome:RGD:1562284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Qpctl1; RGD1562284
Summary
Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Predicted to be involved in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase. Orthologous to human QPCT (glutaminyl-peptide cyclotransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 45.6), Lung (RPKM 41.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (21716824..21748895, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (15964656..15996730, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (1657110..1689575)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene mortality factor 4 like 1, pseudogene 1 Neighboring gene ATP synthase membrane subunit G like 3 Neighboring gene ribosomal protein S17, pseudogene 9 Neighboring gene protein kinase D3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Glutaminyl cyclases as novel targets for the treatment of septic arthritis. Hellvard A, et al. J Infect Dis, 2013 Mar 1. PMID 23204180, Free PMC Article
  2. Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase. Song I, et al. J Mol Endocrinol, 1994 Aug. PMID 7999256
  3. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. Huang KF, et al. J Biol Chem, 2011 Apr 8. PMID 21288892, Free PMC Article
  4. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glutaminyl-peptide cyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminyl-peptide cyclotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
glutaminyl-peptide cyclotransferase
Names
glutaminyl cyclase
glutaminyl-peptide cyclotransferase-like 1
NP_001128029.1
NP_001386445.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134557.3 → NP_001128029.1  glutaminyl-peptide cyclotransferase isoform 2 precursor

    See identical proteins and their annotated locations for NP_001128029.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A0G2K497, A6H9U1, A6H9U2
    Related
    ENSRNOP00000072958.1, ENSRNOT00000079864.3
    Conserved Domains (1) summary
    cd03880
    Location:41 → 310
    M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

  2. NM_001399516.1 → NP_001386445.1  glutaminyl-peptide cyclotransferase isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6H9U2, D4AC85
    Related
    ENSRNOP00000045568.3, ENSRNOT00000049672.6
    Conserved Domains (1) summary
    cd03880
    Location:54 → 359
    M28_QC_like; M28 Zn-peptidase glutaminyl cyclase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    21716824..21748895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools