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CG3626 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31377, updated on 2-Nov-2024

Summary

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Official Symbol
CG3626provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0029706
Locus tag
Dmel_CG3626
See related
AllianceGenome:FB:FBgn0029706
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG3626
Summary
Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity. Predicted to be part of mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex and pyruvate dehydrogenase complex. Predicted to be active in mitochondrial matrix. Is expressed in adult head and spermatozoon. Orthologous to human PDPR (pyruvate dehydrogenase phosphatase regulatory subunit). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG3626 in Genome Data Viewer
Location:
4C2-4C2; 1-8 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4366417..4371136)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4260450..4265169)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43614 Neighboring gene long non-coding RNA:CR46499 Neighboring gene mir-983-1 stem loop Neighboring gene mir-983-2 stem loop Neighboring gene long non-coding RNA:CR32773 Neighboring gene mir-982 stem loop Neighboring gene mir-303 stem loop Neighboring gene mir-984 stem loop Neighboring gene bifid

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Enhancer trap infidelity in Drosophila optomotor-blind. Mayer LR, et al. Fly (Austin), 2013 Apr-Jun. PMID 23519069, Free PMC Article
  2. The alpha-ketoacid dehydrogenase complexes of Drosophila melanogaster. Marygold SJ. MicroPubl Biol, 2024. PMID 38741935, Free PMC Article
  3. Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling. Ermanoska B, et al. Nat Commun, 2023 Mar 8. PMID 36890170, Free PMC Article
  4. Chromosomal distribution of PcG proteins during Drosophila development. Nègre N, et al. PLoS Biol, 2006 Jun. PMID 16613483, Free PMC Article
  5. Testing Implications of the Omnigenic Model for the Genetic Analysis of Loci Identified through Genome-wide Association. Zhang W, et al. Curr Biol, 2021 Mar 8. PMID 33417882

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium-dependent protein serine/threonine phosphatase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pyruvate dehydrogenase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG3626-PA
NP_572162.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4366417..4371136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_131934.2 → NP_572162.2  uncharacterized protein Dmel_CG3626 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572162.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQN6, Q9W4K8
    Related
    FBpp0070620
    Conserved Domains (5) summary
    COG0404
    Location:480 → 908
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    pfam01266
    Location:70 → 429
    DAO; FAD dependent oxidoreductase
    pfam01571
    Location:490 → 774
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:783 → 887
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:432 → 487
    FAO_M; FAD dependent oxidoreductase central domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MQN6 Q8MQN6
Q9W4K8 Q9W4K8

Gene LinkOut

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