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Kazn kazrin, periplakin interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 313672, updated on 10-Jul-2024

Summary

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Official Symbol
Kaznprovided by RGD
Official Full Name
kazrin, periplakin interacting proteinprovided by RGD
Primary source
RGD:1359147
See related
EnsemblRapid:ENSRNOG00000014322 AllianceGenome:RGD:1359147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kaz
Summary
Predicted to be involved in keratinization. Predicted to be located in several cellular components, including cornified envelope; desmosome; and nuclear speck. Orthologous to human KAZN (kazrin, periplakin interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 46.4), Kidney (RPKM 34.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kazn in Genome Data Viewer
Location:
5q36
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (159675803..160666084, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (154392793..155381567, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (160637235..161730513, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene forkhead associated phosphopeptide binding domain 1 Neighboring gene transmembrane protein 51 Neighboring gene uncharacterized LOC134487032 Neighboring gene uncharacterized LOC134487033 Neighboring gene uncharacterized LOC134487030 Neighboring gene uncharacterized LOC134479045 Neighboring gene uncharacterized LOC134479046 Neighboring gene uncharacterized LOC102556543 Neighboring gene uncharacterized LOC120103134 Neighboring gene large ribosomal subunit protein uL5-like Neighboring gene uncharacterized LOC103692503 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene PR/SET domain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane. Groot KR, et al. J Cell Biol, 2004 Aug 30. PMID 15337775, Free PMC Article
  2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105638

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cornified envelope IEA
Inferred from Electronic Annotation
more info
  
located_in cornified envelope ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in desmosome IEA
Inferred from Electronic Annotation
more info
  
located_in desmosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kazrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014070.4 → NP_001014092.2  kazrin isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6AAP0, A6ITY6
    Conserved Domains (1) summary
    pfam13863
    Location:129 → 242
    DUF4200; Domain of unknown function (DUF4200)

  2. NM_001415945.1 → NP_001402874.1  kazrin isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q5FWS6
    UniProtKB/TrEMBL
    A0A0H2UHL8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    159675803..160666084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593423.3 → XP_017448912.1  kazrin isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHL8
    Related
    ENSRNOP00000019447.8, ENSRNOT00000019447.8

  2. XM_006239310.5 → XP_006239372.2  kazrin isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHL8
    Conserved Domains (4) summary
    cd09564
    Location:465 → 534
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:544 → 608
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:630 → 701
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    COG1196
    Location:32 → 262
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_006239311.5 → XP_006239373.1  kazrin isoform X3

    UniProtKB/TrEMBL
    A0A0H2UHL8
    Related
    ENSRNOP00000088366.2, ENSRNOT00000118606.2
    Conserved Domains (6) summary
    cd09564
    Location:437 → 506
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:516 → 580
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:602 → 673
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    smart00454
    Location:437 → 504
    SAM; Sterile alpha motif
    pfam05010
    Location:71 → 246
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam13863
    Location:118 → 231
    DUF4200; Domain of unknown function (DUF4200)

  4. XM_039110084.2 → XP_038966012.1  kazrin isoform X4

    UniProtKB/TrEMBL
    A0A0H2UHL8
    Conserved Domains (4) summary
    cd09564
    Location:349 → 418
    SAM_kazrin_repeat1; SAM domain of kazrin proteins repeat 1
    cd09567
    Location:428 → 492
    SAM_kazrin_repeat2; SAM domain of kazrin proteins repeat 2
    cd09570
    Location:514 → 585
    SAM_kazrin_repeat3; SAM domain of kazrin proteins repeat 3
    COG1196
    Location:25 → 158
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FWS6.2 GenPept UniProtKB/Swiss-Prot:Q5FWS6

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