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tyf twenty-four [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31363, updated on 2-Nov-2024

Summary

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Official Symbol
tyfprovided by FlyBase
Official Full Name
twenty-fourprovided by FlyBase
Primary source
FLYBASE:FBgn0026083
Locus tag
Dmel_CG4857
See related
AllianceGenome:FB:FBgn0026083
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG485; CG4857; Dmel\CG4857; EG:EG0007.12; EG:EG0007.4; TYF
Summary
Involved in defense response to bacterium; locomotor rhythm; and positive regulation of translation. Predicted to be active in cytoplasm and nucleus. Is expressed in embryonic brain and organism. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See tyf in Genome Data Viewer
Location:
4B1-4B1; 1-7 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4117020..4130016)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4011053..4024049)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ciboulot Neighboring gene NOP2-Sun domain family, member 2 Neighboring gene Tat interactive protein 60kDa Neighboring gene dim gamma-tubulin 4 Neighboring gene Glucuronyltransferase I Neighboring gene Fasciclin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of different per translational kinetics on the dynamics of a core circadian clock model. Nieto PS, et al. PLoS One, 2015. PMID 25607544, Free PMC Article
  2. Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons. Xu F, et al. PLoS Genet, 2019 Oct. PMID 31593562, Free PMC Article
  3. Ataxin-2, Twenty-four, and Dicer-2 are components of a noncanonical cytoplasmic polyadenylation complex. Nadimpalli HP, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114004, Free PMC Article
  4. A role for Drosophila ATX2 in activation of PER translation and circadian behavior. Zhang Y, et al. Science, 2013 May 17. PMID 23687048, Free PMC Article
  5. The novel gene twenty-four defines a critical translational step in the Drosophila clock. Lim C, et al. Nature, 2011 Feb 17. PMID 21331043, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 4128176-4128575 mobile_element_type = transposon:INE-1{}2001

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
twenty-four
Names
CG4857-PB
CG4857-PC
CG4857-PF
CG4857-PG
CG4857-PH
CG4857-PI
CG4857-PJ
CG4857-PK
CG4857-PL
CG4857-PM
CG4857-PN
TWENTY-FOUR
twenty four
tyf-PB
tyf-PC
tyf-PF
tyf-PG
tyf-PH
tyf-PI
tyf-PJ
tyf-PK
tyf-PL
tyf-PM
tyf-PN

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4117020..4130016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169186.2 → NP_001162657.1  twenty-four, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162657.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJD4, O97423, O97424, Q9W4M7
    Conserved Domains (1) summary
    cl01868
    Location:1546 → 1622
    YukC; WXG100 protein secretion system (Wss), protein YukC

  2. NM_131924.3 → NP_572152.2  twenty-four, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572152.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJD4, O97423, O97424, Q9W4M7
    Related
    FBpp0070611
    Conserved Domains (1) summary
    cl01868
    Location:1546 → 1622
    YukC; WXG100 protein secretion system (Wss), protein YukC

  3. NM_001169187.2 → NP_001162658.2  twenty-four, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162658.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJD4, O97423, O97424, Q9W4M7
    Conserved Domains (1) summary
    cl01868
    Location:1546 → 1622
    YukC; WXG100 protein secretion system (Wss), protein YukC

  4. NM_001297924.2 → NP_001284853.1  twenty-four, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284853.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJD4, O97423, O97424, Q9W4M7
    Conserved Domains (1) summary
    cl01868
    Location:1546 → 1622
    YukC; WXG100 protein secretion system (Wss), protein YukC

  5. NM_001258590.2 → NP_001245519.1  twenty-four, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245519.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJD4, O97423, O97424, Q9W4M7
    Conserved Domains (1) summary
    cl01868
    Location:1546 → 1622
    YukC; WXG100 protein secretion system (Wss), protein YukC

  6. NM_001258591.2 → NP_001245520.1  twenty-four, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245520.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJD6, E1JJD7
    Conserved Domains (1) summary
    cl01868
    Location:1302 → 1378
    YukC; WXG100 protein secretion system (Wss), protein YukC

  7. NM_001169189.3 → NP_001162660.1  twenty-four, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162660.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJD6, E1JJD7
    Conserved Domains (1) summary
    cl01868
    Location:1302 → 1378
    YukC; WXG100 protein secretion system (Wss), protein YukC

  8. NM_001258592.2 → NP_001245521.1  twenty-four, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245521.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJD6, E1JJD7
    Conserved Domains (1) summary
    cl01868
    Location:1302 → 1378
    YukC; WXG100 protein secretion system (Wss), protein YukC

  9. NM_001258589.2 → NP_001245518.1  twenty-four, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245518.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJD6, E1JJD7
    Conserved Domains (1) summary
    cl01868
    Location:1302 → 1378
    YukC; WXG100 protein secretion system (Wss), protein YukC

  10. NM_001258588.2 → NP_001245517.1  twenty-four, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245517.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJD6, E1JJD7
    Conserved Domains (1) summary
    cl01868
    Location:1302 → 1378
    YukC; WXG100 protein secretion system (Wss), protein YukC

  11. NM_001169188.3 → NP_001162659.2  twenty-four, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162659.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJD6, E1JJD7
    Conserved Domains (1) summary
    cl01868
    Location:1302 → 1378
    YukC; WXG100 protein secretion system (Wss), protein YukC
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JJD6 E1JJD6
Q7K764 Q7K764
Q7K765 Q7K765
Q8MSV7 Q8MSV7
Q95RH4 Q95RH4
Q9W4M7 Q9W4M7

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