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Thrap3 thyroid hormone receptor associated protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313591, updated on 10-Jul-2024

Summary

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Official Symbol
Thrap3provided by RGD
Official Full Name
thyroid hormone receptor associated protein 3provided by RGD
Primary source
RGD:1306129
See related
EnsemblRapid:ENSRNOG00000009977 AllianceGenome:RGD:1306129
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including phosphoprotein binding activity; thyroid hormone receptor binding activity; and transcription coactivator activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process; positive regulation of circadian rhythm; and regulation of RNA metabolic process. Predicted to act upstream of or within circadian rhythm. Predicted to be located in nuclear speck. Predicted to be part of mediator complex. Orthologous to human THRAP3 (thyroid hormone receptor associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 409.0), Spleen (RPKM 333.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Thrap3 in Genome Data Viewer
Location:
5q36
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (143729821..143772105, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (138445284..138487544, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (144178248..144221318, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351032 Neighboring gene eva-1 homolog B Neighboring gene SH3 domain containing 21 Neighboring gene uncharacterized LOC120103176 Neighboring gene MAP7 domain containing 1 Neighboring gene uncharacterized LOC134486990

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing. Heyd F, et al. Mol Cell, 2010 Oct 8. PMID 20932480, Free PMC Article
  2. Regulation of cyclin D1 RNA stability by SNIP1. Bracken CP, et al. Cancer Res, 2008 Sep 15. PMID 18794151, Free PMC Article
  3. A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. Lande-Diner L, et al. Proc Natl Acad Sci U S A, 2013 Oct 1. PMID 24043798, Free PMC Article
  4. TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation. Lee KM, et al. Nucleic Acids Res, 2010 Jun. PMID 20123736, Free PMC Article
  5. Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. Horiuchi K, et al. J Biol Chem, 2013 Nov 15. PMID 24100041, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC94882

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of exon-exon junction complex IEA
Inferred from Electronic Annotation
more info
  
part_of exon-exon junction complex ISO
Inferred from Sequence Orthology
more info
  
part_of exon-exon junction complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
thyroid hormone receptor-associated protein 3
Names
thyroid hormone receptor-associated protein complex 150 kDa component
trap150

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009693.1 → NP_001009693.1  thyroid hormone receptor-associated protein 3

    See identical proteins and their annotated locations for NP_001009693.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088415
    UniProtKB/Swiss-Prot
    Q5M7V8
    UniProtKB/TrEMBL
    A0A8I5ZUG9
    Related
    ENSRNOP00000085793.2, ENSRNOT00000106551.2
    Conserved Domains (1) summary
    pfam15440
    Location:191 → 766
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    143729821..143772105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238867.4 → XP_006238929.1  thyroid hormone receptor-associated protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZUG9, A0A8I6A105
    Conserved Domains (1) summary
    pfam15440
    Location:343 → 595
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

  2. XM_039110014.2 → XP_038965942.1  thyroid hormone receptor-associated protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5M7V8
    UniProtKB/TrEMBL
    A0A8I5ZUG9
    Conserved Domains (1) summary
    pfam15440
    Location:191 → 766
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

  3. XM_039110015.2 → XP_038965943.1  thyroid hormone receptor-associated protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5M7V8
    UniProtKB/TrEMBL
    A0A8I5ZUG9
    Conserved Domains (1) summary
    pfam15440
    Location:191 → 766
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

  4. XM_008764021.4 → XP_008762243.1  thyroid hormone receptor-associated protein 3 isoform X1

    See identical proteins and their annotated locations for XP_008762243.1

    UniProtKB/Swiss-Prot
    Q5M7V8
    UniProtKB/TrEMBL
    A0A8I5ZUG9
    Conserved Domains (1) summary
    pfam15440
    Location:191 → 766
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

  5. XM_063287755.1 → XP_063143825.1  thyroid hormone receptor-associated protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZUG9, A0A8I6A105

  6. XM_008764022.4 → XP_008762244.1  thyroid hormone receptor-associated protein 3 isoform X1

    See identical proteins and their annotated locations for XP_008762244.1

    UniProtKB/Swiss-Prot
    Q5M7V8
    UniProtKB/TrEMBL
    A0A8I5ZUG9
    Conserved Domains (1) summary
    pfam15440
    Location:191 → 766
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

  7. XM_063287753.1 → XP_063143823.1  thyroid hormone receptor-associated protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5M7V8
    UniProtKB/TrEMBL
    A0A8I5ZUG9

  8. XM_063287754.1 → XP_063143824.1  thyroid hormone receptor-associated protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5M7V8
    UniProtKB/TrEMBL
    A0A8I5ZUG9

  9. XM_039110018.2 → XP_038965946.1  thyroid hormone receptor-associated protein 3 isoform X4

    Conserved Domains (1) summary
    pfam15440
    Location:3 → 484
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

  10. XM_063287756.1 → XP_063143826.1  thyroid hormone receptor-associated protein 3 isoform X5

  11. XM_039110017.2 → XP_038965945.1  thyroid hormone receptor-associated protein 3 isoform X3

    Conserved Domains (1) summary
    pfam15440
    Location:191 → 704
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M7V8.1 GenPept UniProtKB/Swiss-Prot:Q5M7V8

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