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Zfyve9 zinc finger FYVE-type containing 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313477, updated on 2-Nov-2024

Summary

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Official Symbol
Zfyve9provided by RGD
Official Full Name
zinc finger FYVE-type containing 9provided by RGD
Primary source
RGD:1310856
See related
EnsemblRapid:ENSRNOG00000027183 AllianceGenome:RGD:1310856
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-phosphatidylinositol binding activity and protein domain specific binding activity. Predicted to be involved in endosomal transport and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of protein-containing complex. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE9 (zinc finger FYVE-type containing 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 162.9), Muscle (RPKM 136.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfyve9 in Genome Data Viewer
Location:
5q34
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (128599379..128758394, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (123370677..123529699, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (128233096..128392675, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene origin recognition complex, subunit 1 Neighboring gene coiled-coil and C2 domain containing 1B Neighboring gene ribosomal protein L9, pseudogene 8 Neighboring gene basic transcription factor 3-like 4 Neighboring gene thioredoxin domain containing 12 Neighboring gene KTI12 chromatin associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Involvement of SARA in Axon and Dendrite Growth. Arias CI, et al. PLoS One, 2015. PMID 26405814, Free PMC Article
  2. [Dynamic characteristics of SARA during liver fibrogenesis in rats]. Tao YY, et al. Zhonghua Gan Zang Bing Za Zhi, 2006 Dec. PMID 17196135
  3. Smad anchor for receptor activation contributes to seizures in temporal lobe epilepsy. Yu W, et al. Synapse, 2017 Mar. PMID 28035691
  4. Early endosomal regulation of Smad-dependent signaling in endothelial cells. Panopoulou E, et al. J Biol Chem, 2002 May 17. PMID 11877415
  5. Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity. Chong PA, et al. J Biol Chem, 2004 Sep 24. PMID 15231848

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger FYVE domain-containing protein 9
Names
zinc finger, FYVE domain containing 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107952.1 → NP_001101422.1  zinc finger FYVE domain-containing protein 9

    See identical proteins and their annotated locations for NP_001101422.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474008
    UniProtKB/TrEMBL
    A6JYW0, D3ZDC7
    Related
    ENSRNOP00000036295.7, ENSRNOT00000037523.8
    Conserved Domains (3) summary
    cd15729
    Location:663 → 730
    FYVE_endofin; FYVE domain found in endofin and similar proteins
    pfam11409
    Location:746 → 784
    SARA; Smad anchor for receptor activation (SARA)
    pfam11979
    Location:1021 → 1373
    DUF3480; Domain of unknown function (DUF3480)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    128599379..128758394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287713.1 → XP_063143783.1  zinc finger FYVE domain-containing protein 9 isoform X4

  2. XM_063287714.1 → XP_063143784.1  zinc finger FYVE domain-containing protein 9 isoform X4

  3. XM_063287711.1 → XP_063143781.1  zinc finger FYVE domain-containing protein 9 isoform X1

    UniProtKB/TrEMBL
    A6JYW0, D3ZDC7

  4. XM_063287712.1 → XP_063143782.1  zinc finger FYVE domain-containing protein 9 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZZV6
    Related
    ENSRNOP00000083771.1, ENSRNOT00000111376.2

  5. XM_039109963.2 → XP_038965891.1  zinc finger FYVE domain-containing protein 9 isoform X1

    UniProtKB/TrEMBL
    A6JYW0, D3ZDC7
    Conserved Domains (3) summary
    cd15729
    Location:663 → 730
    FYVE_endofin; FYVE domain found in endofin and similar proteins
    pfam11409
    Location:746 → 784
    SARA; Smad anchor for receptor activation (SARA)
    pfam11979
    Location:1021 → 1373
    DUF3480; Domain of unknown function (DUF3480)

  6. XM_039109964.2 → XP_038965892.1  zinc finger FYVE domain-containing protein 9 isoform X2

    Conserved Domains (3) summary
    cd15729
    Location:663 → 730
    FYVE_endofin; FYVE domain found in endofin and similar proteins
    pfam11409
    Location:746 → 784
    SARA; Smad anchor for receptor activation (SARA)
    pfam11979
    Location:1021 → 1345
    DUF3480; Domain of unknown function (DUF3480)
Nucleotide Protein Strain
Heading Accession and Version

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