Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bpnt2provided by RGD
Official Full Name: 3'(2'), 5'-bisphosphate nucleotidase 2provided by RGD
Primary source: RGD:1306455
See related: EnsemblRapid:ENSRNOG00000046647 AllianceGenome:RGD:1306455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IMP 3; gPAPP; Impad1; RGD1306455
Summary: Predicted to enable 3',5'-nucleotide bisphosphate phosphatase activity and 3'-nucleotidase activity. Predicted to be involved in skeletal system development. Predicted to act upstream of or within several processes, including chondroitin sulfate metabolic process; embryonic digit morphogenesis; and skeletal system development. Predicted to be located in cytosol; nuclear body; and trans-Golgi network membrane. Predicted to be active in endomembrane system. Human ortholog(s) of this gene implicated in chondrodysplasia with joint dislocations gPAPP type. Orthologous to human BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 77.4), Brain (RPKM 61.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (22573241..22600126, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (17775684..17802570, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (90191119..90218013, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH140766 (e-PCR)
- UniSTS:222832

RH134182 (e-PCR)
- UniSTS:217464

RH139763 (e-PCR)
- UniSTS:221847

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'(2'),5'-bisphosphate nucleotidase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-nucleotide bisphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-nucleotide bisphosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3'-nucleotidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-nucleotidase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within chondrocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chondroitin sulfate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

Names: Ac2-190; Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; IMPase 3; golgi-resident PAP phosphatase; inositol monophosphatase 3; inositol monophosphatase domain containing 1; inositol monophosphatase domain-containing protein 1; inositol-1(or 4)-monophosphatase 3; myo-inositol monophosphatase A3; phosphoadenosine phosphate 3'-nucleotidase

NP_001008772.2

EC 3.1.3.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008772.3 → NP_001008772.2 Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

See identical proteins and their annotated locations for NP_001008772.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

D4AD37

Related

ENSRNOP00000067120.1, ENSRNOT00000072803.3

Conserved Domains (1) summary

cd01640
Location:64 → 347

IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...