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Med21 mediator complex subunit 21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312849, updated on 2-Nov-2024

Summary

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Official Symbol
Med21provided by RGD
Official Full Name
mediator complex subunit 21provided by RGD
Primary source
RGD:1309836
See related
EnsemblRapid:ENSRNOG00000001820 AllianceGenome:RGD:1309836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Surb7
Summary
Contributes to ubiquitin protein ligase activity. Involved in protein ubiquitination. Part of ubiquitin ligase complex. Orthologous to human MED21 (mediator complex subunit 21). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 87.1), Muscle (RPKM 71.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Med21 in Genome Data Viewer
Location:
4q44
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (181291191..181314504)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (179560509..179583811)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (180961194..180968155)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene FGFR1 oncogene partner 2 Neighboring gene transmembrane 7 superfamily member 3 Neighboring gene serine/threonine kinase 38 like Neighboring gene basic helix-loop-helix ARNT like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. Tudor M, et al. Genes Dev, 1999 Sep 15. PMID 10500093, Free PMC Article
  2. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. Ito M, et al. EMBO J, 2002 Jul 1. PMID 12093747, Free PMC Article
  3. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Brower CS, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12149480, Free PMC Article
  4. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Ge K, et al. Nature, 2002 May 30. PMID 12037571
  5. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107895.2 → NP_001101365.2  mediator of RNA polymerase II transcription subunit 21

    See identical proteins and their annotated locations for NP_001101365.2

    Status: VALIDATED

    Source sequence(s)
    CN544042, FM087109
    UniProtKB/TrEMBL
    A6IN28, D4AA11
    Related
    ENSRNOP00000002500.6, ENSRNOT00000002500.9
    Conserved Domains (1) summary
    pfam11221
    Location:1 → 127
    Med21; Subunit 21 of Mediator complex

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    181291191..181314504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107706.2 → XP_038963634.1  mediator of RNA polymerase II transcription subunit 21 isoform X1

    UniProtKB/TrEMBL
    A6IN29
    Conserved Domains (1) summary
    pfam11221
    Location:1 → 86
    Med21; Subunit 21 of Mediator complex

RNA

  1. XR_005503242.2 RNA Sequence

  2. XR_010065650.1 RNA Sequence

  3. XR_005503243.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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