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Recql RecQ like helicase [ Rattus norvegicus (Norway rat) ]

Gene ID: 312824, updated on 2-Nov-2024

Summary

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Official Symbol
Recqlprovided by RGD
Official Full Name
RecQ like helicaseprovided by RGD
Primary source
RGD:1311071
See related
EnsemblRapid:ENSRNOG00000012602 AllianceGenome:RGD:1311071
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA helicase activity and DNA/DNA annealing activity. Predicted to be involved in DNA unwinding involved in DNA replication; double-strand break repair via homologous recombination; and replication fork processing. Predicted to be located in nucleoplasm. Predicted to be active in chromosome and cytoplasm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and pancreatic cancer. Orthologous to human RECQL (RecQ like helicase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 594.1), Lung (RPKM 133.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Recql in Genome Data Viewer
Location:
4q44
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (177039351..177063968, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (175308337..175332965, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (176581892..176606520, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1A5 Neighboring gene islet amyloid polypeptide Neighboring gene uncharacterized LOC102549024 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene golgi transport 1B Neighboring gene spexin hormone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Anticancer activity of RecQL1 helicase siRNA in mouse xenograft models. Futami K, et al. Cancer Sci, 2008 Jun. PMID 18422747, Free PMC Article
  2. Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinoma. Cotton RT, et al. HPB (Oxford), 2009 Aug. PMID 19768149, Free PMC Article
  3. Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4. Xu X, et al. EMBO J, 2009 Mar 4. PMID 19177149, Free PMC Article
  4. Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival. Li D, et al. Cancer Res, 2006 Mar 15. PMID 16540687, Free PMC Article
  5. The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Kume T, et al. Genes Dev, 2001 Sep 15. PMID 11562355, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3'-5' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3'-5' DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA/DNA annealing activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA/DNA annealing activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables four-way junction helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing IEA
Inferred from Electronic Annotation
more info
  
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
involved_in replication fork processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ATP-dependent DNA helicase Q1
Names
DNA 3'-5' helicase Q1
DNA-dependent ATPase Q1
RecQ helicase-like
RecQ protein-like (DNA helicase Q1-like)
recQ protein-like 1
NP_001012098.1
XP_006237679.1
XP_006237680.1
XP_006237681.1
XP_006237682.1
XP_038963628.1
XP_038963629.1
XP_038963630.1
XP_038963631.1
XP_063142235.1
XP_063142236.1
XP_063142237.1
XP_063142239.1
XP_063142240.1
XP_063142241.1
XP_063142242.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012098.1 → NP_001012098.1  ATP-dependent DNA helicase Q1

    See identical proteins and their annotated locations for NP_001012098.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079026
    UniProtKB/Swiss-Prot
    Q6AYJ1
    UniProtKB/TrEMBL
    A0A8I6A2E6, A6IMT6
    Related
    ENSRNOP00000085782.1, ENSRNOT00000114762.2
    Conserved Domains (1) summary
    TIGR00614
    Location:82 → 543
    recQ_fam; ATP-dependent DNA helicase, RecQ family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    177039351..177063968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286166.1 → XP_063142236.1  ATP-dependent DNA helicase Q1 isoform X2

  2. XM_063286171.1 → XP_063142241.1  ATP-dependent DNA helicase Q1 isoform X4

  3. XM_039107702.2 → XP_038963630.1  ATP-dependent DNA helicase Q1 isoform X3

    UniProtKB/Swiss-Prot
    Q6AYJ1
    UniProtKB/TrEMBL
    A0A8I6A2E6, A6IMT6
    Conserved Domains (1) summary
    TIGR00614
    Location:82 → 543
    recQ_fam; ATP-dependent DNA helicase, RecQ family

  4. XM_006237619.5 → XP_006237681.1  ATP-dependent DNA helicase Q1 isoform X1

    See identical proteins and their annotated locations for XP_006237681.1

    UniProtKB/TrEMBL
    A0A8I5Y8C0, A0A8I6A2E6, A6IMT7
    Conserved Domains (1) summary
    TIGR00614
    Location:82 → 543
    recQ_fam; ATP-dependent DNA helicase, RecQ family

  5. XM_063286167.1 → XP_063142237.1  ATP-dependent DNA helicase Q1 isoform X3

    UniProtKB/Swiss-Prot
    Q6AYJ1
    UniProtKB/TrEMBL
    A6IMT6

  6. XM_006237617.4 → XP_006237679.1  ATP-dependent DNA helicase Q1 isoform X1

    See identical proteins and their annotated locations for XP_006237679.1

    UniProtKB/TrEMBL
    A0A8I5Y8C0, A0A8I6A2E6, A6IMT7
    Conserved Domains (1) summary
    TIGR00614
    Location:82 → 543
    recQ_fam; ATP-dependent DNA helicase, RecQ family

  7. XM_063286165.1 → XP_063142235.1  ATP-dependent DNA helicase Q1 isoform X2

  8. XM_063286170.1 → XP_063142240.1  ATP-dependent DNA helicase Q1 isoform X4

  9. XM_039107703.2 → XP_038963631.1  ATP-dependent DNA helicase Q1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A2E6
    Conserved Domains (1) summary
    TIGR00614
    Location:82 → 543
    recQ_fam; ATP-dependent DNA helicase, RecQ family

  10. XM_039107701.2 → XP_038963629.1  ATP-dependent DNA helicase Q1 isoform X3

    UniProtKB/Swiss-Prot
    Q6AYJ1
    UniProtKB/TrEMBL
    A0A8I6A2E6, A6IMT6
    Conserved Domains (1) summary
    TIGR00614
    Location:82 → 543
    recQ_fam; ATP-dependent DNA helicase, RecQ family

  11. XM_006237618.2 → XP_006237680.1  ATP-dependent DNA helicase Q1 isoform X1

    See identical proteins and their annotated locations for XP_006237680.1

    UniProtKB/TrEMBL
    A0A8I5Y8C0, A0A8I6A2E6, A6IMT7
    Related
    ENSRNOP00000077921.1, ENSRNOT00000110058.2
    Conserved Domains (1) summary
    TIGR00614
    Location:82 → 543
    recQ_fam; ATP-dependent DNA helicase, RecQ family

  12. XM_006237620.5 → XP_006237682.1  ATP-dependent DNA helicase Q1 isoform X1

    See identical proteins and their annotated locations for XP_006237682.1

    UniProtKB/TrEMBL
    A0A8I5Y8C0, A0A8I6A2E6, A6IMT7
    Conserved Domains (1) summary
    TIGR00614
    Location:82 → 543
    recQ_fam; ATP-dependent DNA helicase, RecQ family

  13. XM_039107700.2 → XP_038963628.1  ATP-dependent DNA helicase Q1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A2E6
    Related
    ENSRNOP00000060671.2, ENSRNOT00000065576.4
    Conserved Domains (1) summary
    TIGR00614
    Location:82 → 543
    recQ_fam; ATP-dependent DNA helicase, RecQ family

  14. XM_063286169.1 → XP_063142239.1  ATP-dependent DNA helicase Q1 isoform X3

    UniProtKB/Swiss-Prot
    Q6AYJ1
    UniProtKB/TrEMBL
    A6IMT6

  15. XM_063286172.1 → XP_063142242.1  ATP-dependent DNA helicase Q1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYJ1.1 GenPept UniProtKB/Swiss-Prot:Q6AYJ1

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