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Atf7ip activating transcription factor 7 interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 312800, updated on 2-Nov-2024

Summary

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Official Symbol
Atf7ipprovided by RGD
Official Full Name
activating transcription factor 7 interacting proteinprovided by RGD
Primary source
RGD:1306030
See related
EnsemblRapid:ENSRNOG00000008870 AllianceGenome:RGD:1306030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity and transcription corepressor activity. Predicted to be involved in protein stabilization and regulation of gene expression. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear body. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human ATF7IP (activating transcription factor 7 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 244.0), Spleen (RPKM 208.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atf7ip in Genome Data Viewer
Location:
4q43
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (171117122..171202871)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (169385872..169471652)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (170476998..170563063)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486855 Neighboring gene uncharacterized LOC120102185 Neighboring gene uncharacterized LOC102549638 Neighboring gene phospholipase B domain containing 1 Neighboring gene guanylate cyclase 2C Neighboring gene uncharacterized LOC134486648

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MCAF mediates MBD1-dependent transcriptional repression. Fujita N, et al. Mol Cell Biol, 2003 Apr. PMID 12665582, Free PMC Article
  2. ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex. Timms RT, et al. Cell Rep, 2016 Oct 11. PMID 27732843, Free PMC Article
  3. A murine ATFa-associated factor with transcriptional repressing activity. De Graeve F, et al. Oncogene, 2000 Mar 30. PMID 10777215
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
activating transcription factor 7-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107893.3 → NP_001101363.2  activating transcription factor 7-interacting protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I5ZNS2
    Related
    ENSRNOP00000107375.1, ENSRNOT00000146270.1
    Conserved Domains (4) summary
    PTZ00121
    Location:410 → 705
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:694 → 1213
    PHA03247; large tegument protein UL36; Provisional
    pfam16788
    Location:604 → 815
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1199 → 1299
    fn3_4; Fibronectin-III type domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    171117122..171202871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286153.1 → XP_063142223.1  activating transcription factor 7-interacting protein 1 isoform X1

    Related
    ENSRNOP00000079952.2, ENSRNOT00000113634.2

  2. XM_063286156.1 → XP_063142226.1  activating transcription factor 7-interacting protein 1 isoform X4

  3. XM_063286157.1 → XP_063142227.1  activating transcription factor 7-interacting protein 1 isoform X5

  4. XM_063286154.1 → XP_063142224.1  activating transcription factor 7-interacting protein 1 isoform X2

    Related
    ENSRNOP00000110923.1, ENSRNOT00000164196.1

  5. XM_063286155.1 → XP_063142225.1  activating transcription factor 7-interacting protein 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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