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crm cramped [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31268, updated on 28-Oct-2024

Summary

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Official Symbol
crmprovided by FlyBase
Official Full Name
crampedprovided by FlyBase
Primary source
FLYBASE:FBgn0000376
Locus tag
Dmel_CG2714
See related
AllianceGenome:FB:FBgn0000376
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2714; Crm; Dmel\CG2714; EG:95B7.2; l(1)3C1; l(1)3Ca; l(1)zw9; sa; sta[P]; swa; zw-9; ZW-9; zw9
Summary
Enables chromatin binding activity. Involved in segment specification. Located in nucleus. Is expressed in several structures, including embryonic brain; embryonic/larval salivary gland; gonad; presumptive embryonic/larval nervous system; and primordial germ cell. Orthologous to human CRAMP1 (cramped chromatin regulator homolog 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See crm in Genome Data Viewer
Location:
3B3-3B4; 1-1.5 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2734248..2738773, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2628281..2632806, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43494 Neighboring gene uncharacterized protein Neighboring gene tiny tim 50 Neighboring gene deformed wings Neighboring gene kin of irre Neighboring gene Syntaxin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic effects associated with band 3C1 of the salivary gland X chromosome of Drosophila melanogaster. Gersh ES. Genetics, 1967 Jun. PMID 6040496, Free PMC Article
  2. The Drosophila Broad-Complex encodes a family of related proteins containing zinc fingers. DiBello PR, et al. Genetics, 1991 Oct. PMID 1743483, Free PMC Article
  3. Molecular analysis of the ecdysterone-inducible 2B5 "early' puff in Drosophila melanogaster. Chao AT, et al. EMBO J, 1986 Jan. PMID 3007111, Free PMC Article
  4. The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding Proliferating Cell Nuclear Antigen. Yamamoto Y, et al. Development, 1997 Sep. PMID 9310333
  5. Cytogenetic fine structure and chromosomal localization of the white gene in Drosophila melanogaster. Sorsa V, et al. Nat New Biol, 1973 Sep 12. PMID 4125726

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRM is specifically required for the expression of the Histone H1 gene.
    Title: The Polycomb group protein CRAMPED is involved with TRF2 in the activation of the histone H1 gene.
  2. crm modulates the effect of temperature on a genomic region encoding Hedgehog and Wingless signaling effectors.
    Title: Segregating variation in the polycomb group gene cramped alters the effect of temperature on multiple traits.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in segment specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cramped
Names
CG2714-PA
CG2714-PB
crm-PA
crm-PB
sparse-arista
stubarista from P32
swollen-antenna

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2734248..2738773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166951.2 → NP_726829.1  cramped, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726829.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76906, Q0KHW5, Q8MM10, Q8MM41, Q8MM71, Q8MX89, Q8MX90, Q8MX91, Q8MX92, Q8MX93, Q8MX94, Q8MX95, Q9W4V7
    Related
    FBpp0070472
    Conserved Domains (2) summary
    smart00717
    Location:111 → 171
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:113 → 167
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  2. NM_057757.4 → NP_477105.2  cramped, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477105.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76906, Q0KHW5, Q8MM10, Q8MM41, Q8MM71, Q8MX89, Q8MX90, Q8MX91, Q8MX92, Q8MX93, Q8MX94, Q8MX95, Q9W4V7
    Related
    FBpp0070473
    Conserved Domains (2) summary
    smart00717
    Location:111 → 171
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:113 → 167
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76906.2 O76906

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